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<p>This prospective study aimed to investigate colonization of <i>Ureaplasma</i> spp. in preterm infants to evaluate the relationship between <i>Ureaplasma</i> spp. colonization and BPD including other neonatal morbidities. A cohort of 357 preterm infants was examined for <i>Ureaplasma</i> spp. detection. Samples as nasopharyngeal swabs and gastric aspirates (non-intubated infants) whereas tracheal aspirates (intubated infants), were collected within 24&#xa0;h of birth from infants with &lt; 37&#xa0;weeks gestational age (GA). Each sample was tested with culture and real-time polymerase chain reaction (RT-PCR) to confirm <i>Ureaplasma</i> spp. colonization. A total of 12 (3.3%) preterm infants (GA, 30.5 ± 2.2&#xa0;weeks, P = 0.001; BW, 1,529 ± 501&#xa0;g, P = 0.005) were positive for <i>Ureaplasma</i> spp. colonization. 23 (6.8%) preterm infants (GA, 28.7 ± 1.1&#xa0;weeks, P = 0.001; BW, 1,234 ± 441&#xa0;g, P = 0.005) developed BPD. <i>Ureaplasma</i> spp. colonization and BPD development showed an inverse relation with GA and birth weight (BW), and were associated with one antenatal factor (premature rupture of membranes; PROM), two natal factors (smaller GA, lower BW), one postnatal factor (longer use of supplemental oxygen), and p-value was significant for all factors (P &lt; 0.05). Incidence of BPD in <i>Ureaplasma</i> spp. positive group was higher than in <i>Ureaplasma</i> spp. negative group (n = 3, 25% vs. n = 20, 6%, P = 0.001). Multivariate logistic regression analysis revealed a common correlation of <i>Ureaplasma</i> spp. colonization and BPD development with smaller GA (P = 0.012 &amp; 0.001; 95%CI: 0.590–0.937 &amp; 0.181–0.627), independent correlation of <i>Ureaplasma</i> spp. colonization with PROM (P = 0.002; 95%CI: 2.226–35.547) whereas independent correlation of BPD development with <i>Ureaplasma</i> spp. colonization (P = 0.037; 95%CI: 1.167–123.809) and more ventilator days (P = 0.003; 95%CI: 1.197–2.486). <i>Ureaplasma</i> spp. colonization is associated with PROM, smaller GA, and higher incidence of BPD. All preterm infants delivered by mothers with PROM and/or with smaller GAs should be investigated for <i>Ureaplasma</i> spp. colonization to anticipate BPD incidence.</p>

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Clinical significance of Ureaplasma species in bronchopulmonary dysplasia development in preterm infants

  • 期刊论文

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  • 发表日期：

    2025年9月29日

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  • Hafiz Muhammad Sohail Sarwar,
  • Qingfei Hao,
  • Jing Zhang,
  • Yanna Du,
  • Haoming Chen,
  • Mohammed Awadh Abdun,
  • Jing Chen,
  • Jing Li,
  • Xiuyong Cheng

摘要

This prospective study aimed to investigate colonization of Ureaplasma spp. in preterm infants to evaluate the relationship between Ureaplasma spp. colonization and BPD including other neonatal morbidities. A cohort of 357 preterm infants was examined for Ureaplasma spp. detection. Samples as nasopharyngeal swabs and gastric aspirates (non-intubated infants) whereas tracheal aspirates (intubated infants), were collected within 24 h of birth from infants with < 37 weeks gestational age (GA). Each sample was tested with culture and real-time polymerase chain reaction (RT-PCR) to confirm Ureaplasma spp. colonization. A total of 12 (3.3%) preterm infants (GA, 30.5 ± 2.2 weeks, P = 0.001; BW, 1,529 ± 501 g, P = 0.005) were positive for Ureaplasma spp. colonization. 23 (6.8%) preterm infants (GA, 28.7 ± 1.1 weeks, P = 0.001; BW, 1,234 ± 441 g, P = 0.005) developed BPD. Ureaplasma spp. colonization and BPD development showed an inverse relation with GA and birth weight (BW), and were associated with one antenatal factor (premature rupture of membranes; PROM), two natal factors (smaller GA, lower BW), one postnatal factor (longer use of supplemental oxygen), and p-value was significant for all factors (P < 0.05). Incidence of BPD in Ureaplasma spp. positive group was higher than in Ureaplasma spp. negative group (n = 3, 25% vs. n = 20, 6%, P = 0.001). Multivariate logistic regression analysis revealed a common correlation of Ureaplasma spp. colonization and BPD development with smaller GA (P = 0.012 & 0.001; 95%CI: 0.590–0.937 & 0.181–0.627), independent correlation of Ureaplasma spp. colonization with PROM (P = 0.002; 95%CI: 2.226–35.547) whereas independent correlation of BPD development with Ureaplasma spp. colonization (P = 0.037; 95%CI: 1.167–123.809) and more ventilator days (P = 0.003; 95%CI: 1.197–2.486). Ureaplasma spp. colonization is associated with PROM, smaller GA, and higher incidence of BPD. All preterm infants delivered by mothers with PROM and/or with smaller GAs should be investigated for Ureaplasma spp. colonization to anticipate BPD incidence.