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<p>Reduced field-of-view diffusion-weighted imaging (reduced-FOV DWI) is a promising technique for assessing tumor heterogeneity and microstructure. In this study, we evaluated the ability of reduced-FOV DWI to identify specific patterns associated with human papillomavirus (HPV) exposure in head and neck squamous cell carcinoma (HNSCC). Whole-lesion analysis of the tumor was performed on reduced-FOV and conventional DWI using a multi b value sequence. The extracted parameters included the 10th-90th percentile of the apparent diffusion coefficient (ADC) and fractional blood volume (fBV), skewness, and kurtosis. The differences between HPV-negative and HPV-positive tumors were greater for reduced-FOV DWI. ADC was significantly lower in HPV-positive tumors (reduced-FOV DWI: <i>p</i> &lt; 0.001, <i>r</i><sub><i>90th</i></sub> = 0.50; conventional DWI: <i>p</i> &lt; 0.001, <i>r</i><sub><i>10th</i></sub> = 0.49). The fBV was significantly lower in HPV-positive tumors on reduced-FOV DWI (reduced-FOV DWI: <i>p</i><sub><i>90th</i></sub> &lt; 0.001, <i>r</i><sub><i>90th</i></sub> = 0.47; conventional DWI: not statistically significant). Moreover, there were significant differences between parameters derived from reduced-FOV and conventional DWI (ADC: <i>p</i><sub><i>10th−90th</i></sub> &lt; 0.001, fBV: <i>p</i><sub><i>10th−50th</i></sub> &lt; 0.001; skewness<sub>ADC, fBV</sub>: <i>p</i> &lt; 0.001, kurtosis<sub>ADC</sub>: <i>p</i> = 0.008; kurtosis<sub>fBV</sub>: <i>p</i> &lt; 0.001). In conclusion, DWI parameters varied depending on HPV status and the differences between HPV-positive and HPV-negative tumors were greater for reduced-FOV DWI. The reduced-FOV DWI better reflected histopathology than did conventional DWI.</p>

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Reduced field-of-view DWI outperforms conventional DWI in assessing tumor heterogeneity and HPV status in head and neck cancer

  • 期刊论文

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  • 发表日期：

    2025年8月29日

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  • Marta D. Switlyk,
  • Einar Dale,
  • Svetlana Tafjord,
  • Lise Willumsen,
  • Knut H. Hole,
  • Tord Hompland

摘要

Reduced field-of-view diffusion-weighted imaging (reduced-FOV DWI) is a promising technique for assessing tumor heterogeneity and microstructure. In this study, we evaluated the ability of reduced-FOV DWI to identify specific patterns associated with human papillomavirus (HPV) exposure in head and neck squamous cell carcinoma (HNSCC). Whole-lesion analysis of the tumor was performed on reduced-FOV and conventional DWI using a multi b value sequence. The extracted parameters included the 10th-90th percentile of the apparent diffusion coefficient (ADC) and fractional blood volume (fBV), skewness, and kurtosis. The differences between HPV-negative and HPV-positive tumors were greater for reduced-FOV DWI. ADC was significantly lower in HPV-positive tumors (reduced-FOV DWI: p < 0.001, r90th = 0.50; conventional DWI: p < 0.001, r10th = 0.49). The fBV was significantly lower in HPV-positive tumors on reduced-FOV DWI (reduced-FOV DWI: p90th < 0.001, r90th = 0.47; conventional DWI: not statistically significant). Moreover, there were significant differences between parameters derived from reduced-FOV and conventional DWI (ADC: p10th−90th < 0.001, fBV: p10th−50th < 0.001; skewnessADC, fBV: p < 0.001, kurtosisADC: p = 0.008; kurtosisfBV: p < 0.001). In conclusion, DWI parameters varied depending on HPV status and the differences between HPV-positive and HPV-negative tumors were greater for reduced-FOV DWI. The reduced-FOV DWI better reflected histopathology than did conventional DWI.