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<p>Lower respiratory tract infections (LRTIs) are a significant cause of morbidity and mortality in pediatric populations worldwide. This study examines cerebral oxygenation (StO<sub>2</sub>) in children with LRTIs using Time-Domain Near-Infrared Spectroscopy (TD-NIRS) device (PIONIRS S.r.l., Milan, Italy), a non-invasive tool that allows for measurement of cerebral StO<sub>2</sub>in real-time. An observational case-control study was conducted, including 60 participants: 30 patients with LRTIs and 30 age and sex matched controls. We evaluated the correlation between cerebral StO<sub>2</sub> and various clinical and physiological parameters and we used a multivariate logistic regression analysis explore predictors of LRTI. Cerebral StO<sub>2</sub> was one of the key and independent predictors of LRTIs (OR = 0.45, <i>p</i> = 0.002) suggesting it could be an additional parameter to record for better assessing the condition of LRTI patients. These findings highlight the role of TD-NIRS in providing deeper insights into brain oxygenation in pediatric patients, independent of peripheral measurements such as peripheral oxygen saturation (SpO<sub>2</sub>).</p>

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The role of cerebral oxygenation in pediatric lower respiratory tract infections based on insights from time domain near infrared spectroscopy tissue oximetry

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月25日

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  • Michele Lacerenza,
  • Valeria Calcaterra,
  • Virginia Rossi,
  • Sara Zanelli,
  • Mauro Buttafava,
  • Maria Pia Sormani,
  • Davide Contini,
  • Alessandro Torricelli,
  • Gianvincenzo Zuccotti

摘要

Lower respiratory tract infections (LRTIs) are a significant cause of morbidity and mortality in pediatric populations worldwide. This study examines cerebral oxygenation (StO2) in children with LRTIs using Time-Domain Near-Infrared Spectroscopy (TD-NIRS) device (PIONIRS S.r.l., Milan, Italy), a non-invasive tool that allows for measurement of cerebral StO2in real-time. An observational case-control study was conducted, including 60 participants: 30 patients with LRTIs and 30 age and sex matched controls. We evaluated the correlation between cerebral StO2 and various clinical and physiological parameters and we used a multivariate logistic regression analysis explore predictors of LRTI. Cerebral StO2 was one of the key and independent predictors of LRTIs (OR = 0.45, p = 0.002) suggesting it could be an additional parameter to record for better assessing the condition of LRTI patients. These findings highlight the role of TD-NIRS in providing deeper insights into brain oxygenation in pediatric patients, independent of peripheral measurements such as peripheral oxygen saturation (SpO2).