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<p>If iPS cells can be established easily and efficiently using freshly collected blood cells, it will enhance regenerative and personalized medicine. While reports of iPS derivation from blood-derived endothelial progenitor cells using RNA have been documented, none have been reported from peripheral blood-derived mononuclear cells (PBMCs). In this study, we established a method to generate iPS cells from PBMCs using synthetic RNAs and found that MDM4, which suppresses p53, improved reprogramming efficiency.</p>

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MDM4 enables efficient human iPS cell generation from PBMCs using synthetic RNAs

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月8日

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  • Masato Nakagawa,
  • Mizuho Nogi,
  • Hatsuki Doi,
  • Ryuhei Hayashi,
  • Tomohiko Katayama,
  • Hirohisa Ohno,
  • Megumi Mochizuki,
  • Karin Hayashi,
  • Hirohide Saito

摘要

If iPS cells can be established easily and efficiently using freshly collected blood cells, it will enhance regenerative and personalized medicine. While reports of iPS derivation from blood-derived endothelial progenitor cells using RNA have been documented, none have been reported from peripheral blood-derived mononuclear cells (PBMCs). In this study, we established a method to generate iPS cells from PBMCs using synthetic RNAs and found that MDM4, which suppresses p53, improved reprogramming efficiency.