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<p>Sleep patterns are important predictors of long-term health outcomes. We investigated the associations of sleep duration, sleep regularity, and their combinations with all-cause mortality and cardiovascular events in a large Korean cohort, including sex-specific analyses. This prospective cohort study included 9,641 adults aged 40–69 years from the Ansung–Ansan cohort in Korea. Participants were categorized by self-reported sleep duration (&lt; 7&#xa0;h, 7–8&#xa0;h, or &gt; 8&#xa0;h) and regularity (regular vs. irregular). Outcomes included all-cause mortality and major adverse cardiovascular events (MACE) over a median follow-up of 186 months, during which 1,095 deaths and 811 MACE occurred. Sleep duration &gt; 8&#xa0;h was associated with increased all-cause mortality (adjusted hazard ratio [HR], 1.27; 95% confidence interval [CI], 1.04–1.54). Combined analysis showed higher mortality in those with &lt; 7&#xa0;h and irregular sleep (adjusted HR, 1.28; 95% CI, 1.04–1.58) and &gt; 8&#xa0;h and regular sleep (adjusted HR, 1.26; 95% CI, 1.01–1.58). In sex-specific analyses, sleep duration and regularity were differentially associated with mortality. In women, &gt; 8&#xa0;h of irregular sleep was associated with increased risk, while in men, &lt; 7&#xa0;h of irregular or &gt; 8&#xa0;h of regular sleep showed similar associations. These findings support tailored strategies considering both sleep characteristics and sex.</p>

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The impact of sleep health on cardiovascular and all-cause mortality in the general population

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月16日

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  • Soo Jung Park,
  • Jinsun Park,
  • Byung Sik Kim,
  • Jin-Kyu Park

摘要

Sleep patterns are important predictors of long-term health outcomes. We investigated the associations of sleep duration, sleep regularity, and their combinations with all-cause mortality and cardiovascular events in a large Korean cohort, including sex-specific analyses. This prospective cohort study included 9,641 adults aged 40–69 years from the Ansung–Ansan cohort in Korea. Participants were categorized by self-reported sleep duration (< 7 h, 7–8 h, or > 8 h) and regularity (regular vs. irregular). Outcomes included all-cause mortality and major adverse cardiovascular events (MACE) over a median follow-up of 186 months, during which 1,095 deaths and 811 MACE occurred. Sleep duration > 8 h was associated with increased all-cause mortality (adjusted hazard ratio [HR], 1.27; 95% confidence interval [CI], 1.04–1.54). Combined analysis showed higher mortality in those with < 7 h and irregular sleep (adjusted HR, 1.28; 95% CI, 1.04–1.58) and > 8 h and regular sleep (adjusted HR, 1.26; 95% CI, 1.01–1.58). In sex-specific analyses, sleep duration and regularity were differentially associated with mortality. In women, > 8 h of irregular sleep was associated with increased risk, while in men, < 7 h of irregular or > 8 h of regular sleep showed similar associations. These findings support tailored strategies considering both sleep characteristics and sex.