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<p>The DJ-1 protein, known as an oxidative stress sensor, plays an important role in immunological processes. Using DJ-1 gene knock-out mice, we identified DJ-1 as a positive regulator in systemic lupus erythematosus (SLE). DJ-1 deficiency significantly alleviated skin lesion, splenomegaly, lymphadenopathy, while reducing multiple autoantibodies and immunoglobulin levels. Moreover, DJ-1 deficiency provided protection against renal hypertrophy and decreased glomerular deposition of immunoglobulin, ultimately leading to reduced albuminuria and SLE activity. These findings demonstrate that DJ-1 expression critically influences the progression of lupus-like disease.</p>

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Inhibition of DJ-1 protects from lupus onset and severity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月25日

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  • Mengdi Jiang,
  • Minhui Wang,
  • Liyan Wan,
  • Shuangshuang Li,
  • Chuanyin Sun,
  • Heng Cao,
  • Chaohui Yu,
  • Jin Lin

摘要

The DJ-1 protein, known as an oxidative stress sensor, plays an important role in immunological processes. Using DJ-1 gene knock-out mice, we identified DJ-1 as a positive regulator in systemic lupus erythematosus (SLE). DJ-1 deficiency significantly alleviated skin lesion, splenomegaly, lymphadenopathy, while reducing multiple autoantibodies and immunoglobulin levels. Moreover, DJ-1 deficiency provided protection against renal hypertrophy and decreased glomerular deposition of immunoglobulin, ultimately leading to reduced albuminuria and SLE activity. These findings demonstrate that DJ-1 expression critically influences the progression of lupus-like disease.