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<p>This study aims to investigate the structural and enzymatic effects of Catechin (K) and gallic acid (G) in the treatment of nephrotoxicity and hepatotoxicity induced by cisplatin. Cisplatin (cis-[Pt(NH<sub>3</sub>)<sub>2</sub>Cl<sub>2</sub>]), while commonly used as a cancer treatment, can have toxic effects on the kidneys and liver. In the study, cisplatin (15&#xa0;mg/kg) was administered intraperitoneally to rats to induce toxicity, and then Catechin (C<sub>15</sub>H<sub>14</sub>O<sub>6</sub>) (20&#xa0;mg/kg) and gallic acid (3,4,5-Trihydroxybenzoic acid) (100&#xa0;mg/kg) were administered by oral gavage for 4&#xa0;weeks. The experimental results showed that cisplatin treatment caused a loss of body weight, as well as reductions in kidney and liver weights. Significant damage to kidney and liver tissues was observed, along with increased serum levels of urea, creatinine, BUN, AST, ALT, and tissue levels of MDA. Additionally, increased levels of GPx and GSR were recorded. The results suggest that catechin and gallic acid significantly ameliorate cisplatin-induced kidney and liver damage.</p>

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Protective structural and enzymatic roles of catechin and gallic acid against nephrotoxicity and hepatotoxicity ınduced by cisplatin

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月14日

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  • Nur Sevim Kalkan,
  • Alpaslan Gökçimen

摘要

This study aims to investigate the structural and enzymatic effects of Catechin (K) and gallic acid (G) in the treatment of nephrotoxicity and hepatotoxicity induced by cisplatin. Cisplatin (cis-[Pt(NH3)2Cl2]), while commonly used as a cancer treatment, can have toxic effects on the kidneys and liver. In the study, cisplatin (15 mg/kg) was administered intraperitoneally to rats to induce toxicity, and then Catechin (C15H14O6) (20 mg/kg) and gallic acid (3,4,5-Trihydroxybenzoic acid) (100 mg/kg) were administered by oral gavage for 4 weeks. The experimental results showed that cisplatin treatment caused a loss of body weight, as well as reductions in kidney and liver weights. Significant damage to kidney and liver tissues was observed, along with increased serum levels of urea, creatinine, BUN, AST, ALT, and tissue levels of MDA. Additionally, increased levels of GPx and GSR were recorded. The results suggest that catechin and gallic acid significantly ameliorate cisplatin-induced kidney and liver damage.