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<p>This study assessed the association between chronic kidney disease (CKD) and presbycusis and investigated whether inflammatory neutrophil percentage-to-albumin ratio (NPAR) indicators influence this relationship. This study used data from the National Health and Nutrition Examination Survey and employed methods such as restricted cubic spline analysis, multiple logistic regression analyses, and mediation analyses to explore these relationships. High-frequency hearing impairment (HI) was correlated with moderate CKD (OR = 3.25, 95% CI:1.25- 8.46, <i>P</i> = 0.02). HI grades were correlated with moderate CKD [for slight HI, (OR = 5.13, 95% CI:1.48- 17.86, <i>P</i> = 0.01); for moderate and severe HI, (OR = 4.68, 95% CI:1.29 -17.04, <i>P</i> = 0.02)]. Mediation analysis revealed that NPAR had a 17.85% mediating effect on the association between moderate CKD and presbycusis. Moderate CKD was associated with high-frequency HI in the elderly, and NPAR had a significant mediating effect on this relationship.</p>

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Inflammatory mediation by neutrophil percentage to albumin ratio in the association between chronic kidney disease and presbycusis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月17日

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  • Qingling Wang,
  • Ruizhe Huang,
  • Shiduo Guo,
  • Zhenju Xu,
  • Yichuan Huang,
  • Dapeng Liang,
  • Xiangdong Guo,
  • Liwei Jiang

摘要

This study assessed the association between chronic kidney disease (CKD) and presbycusis and investigated whether inflammatory neutrophil percentage-to-albumin ratio (NPAR) indicators influence this relationship. This study used data from the National Health and Nutrition Examination Survey and employed methods such as restricted cubic spline analysis, multiple logistic regression analyses, and mediation analyses to explore these relationships. High-frequency hearing impairment (HI) was correlated with moderate CKD (OR = 3.25, 95% CI:1.25- 8.46, P = 0.02). HI grades were correlated with moderate CKD [for slight HI, (OR = 5.13, 95% CI:1.48- 17.86, P = 0.01); for moderate and severe HI, (OR = 4.68, 95% CI:1.29 -17.04, P = 0.02)]. Mediation analysis revealed that NPAR had a 17.85% mediating effect on the association between moderate CKD and presbycusis. Moderate CKD was associated with high-frequency HI in the elderly, and NPAR had a significant mediating effect on this relationship.