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<p>Early diagnosis of refractory <i>Mycoplasma pneumoniae</i> pneumonia (RMPP) in children presents significant clinical challenges. Emerging evidence suggests that circ_0054633 may serve as a promising diagnostic biomarker for pulmonary infections. We developed a comprehensive nomogram integrating circ_0054633 expression with clinical features to evaluate its predictive efficacy for early RMPP diagnosis in children. This retrospective study analyzed 244 children with <i>Mycoplasma pneumoniae</i> pneumonia (MPP) admitted to Tianjin Children’s Hospital during 2023. Multivariate analysis identified six independent predictors: elevated circ_0054633 (OR = 6.28, 95% CI: 2.73–14.47), prolonged fever duration (OR = 1.50, 95% CI: 1.24–1.81), hypoxemia (OR = 10.64, 95% CI: 2.75–41.20), extrapulmonary complications (OR = 2.95, 95% CI: 1.17–7.40), elevated IL-6 (OR = 1.02, 95% CI: 1.00-1.03), and atelectasis (OR = 3.16, 95% CI: 1.25-8.00). The nomogram demonstrated excellent discrimination (AUC = 0.920) and calibration. RMPP patients required longer hospitalization (median 9 vs. 7 days, <i>P</i> &lt; 0.001) and more interventions. The circ_0054633-based nomogram, incorporating clinical predictors, exhibits strong predictive value for RMPP in children. Serum circ_0054633 shows promise as a novel diagnostic biomarker for RMPP.</p>

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Combining circ_0054633 and clinical features to predict refractory Mycoplasma pneumoniae pneumonia in children

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月26日

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  • Shiyin Mu,
  • Jia Zhai,
  • Yongsheng Guo,
  • Bing Huang,
  • Yingxue Zou

摘要

Early diagnosis of refractory Mycoplasma pneumoniae pneumonia (RMPP) in children presents significant clinical challenges. Emerging evidence suggests that circ_0054633 may serve as a promising diagnostic biomarker for pulmonary infections. We developed a comprehensive nomogram integrating circ_0054633 expression with clinical features to evaluate its predictive efficacy for early RMPP diagnosis in children. This retrospective study analyzed 244 children with Mycoplasma pneumoniae pneumonia (MPP) admitted to Tianjin Children’s Hospital during 2023. Multivariate analysis identified six independent predictors: elevated circ_0054633 (OR = 6.28, 95% CI: 2.73–14.47), prolonged fever duration (OR = 1.50, 95% CI: 1.24–1.81), hypoxemia (OR = 10.64, 95% CI: 2.75–41.20), extrapulmonary complications (OR = 2.95, 95% CI: 1.17–7.40), elevated IL-6 (OR = 1.02, 95% CI: 1.00-1.03), and atelectasis (OR = 3.16, 95% CI: 1.25-8.00). The nomogram demonstrated excellent discrimination (AUC = 0.920) and calibration. RMPP patients required longer hospitalization (median 9 vs. 7 days, P < 0.001) and more interventions. The circ_0054633-based nomogram, incorporating clinical predictors, exhibits strong predictive value for RMPP in children. Serum circ_0054633 shows promise as a novel diagnostic biomarker for RMPP.