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<p>The tumor microenvironment (TME), particularly CD8<sup>+</sup> T cell infiltration, critically influences high-grade serous ovarian cancer (HGSOC) progression and treatment response. The development and management of cancer depend heavily on CD8<sup>+</sup> T cells. Identifying non-invasive predictors of TME immune status is crucial. We investigated whether clinicopathologic characteristics and peripheral blood parameters could predict CD8<sup>+</sup> T infiltration in TME of HGSOC. Two independent cohort were analyzed: (1) A multicenter tissue microarray (TMA) cohort of 105 epithelial ovarian cancer cases revealed that high CD8<sup>+</sup> T cell density in tumor parenchyma, stroma, or whole tissue was significantly associated with good prognosis. (2) A retrospective cohort of 95 HGSOC patients from West China Second University Hospital (2016–2020) demonstrated that peripheral blood lymphocytes, globulin (GLB), lactate dehydrogenase (LDH), and low-density lipoprotein (LDL) correlated with CD8<sup>+</sup> T cell infiltration in TME. These findings support non-invasive blood markers as predictors of tumor immune status and highlight chemotherapy’s role in enhancing CD8<sup>+</sup> T cell recruitment.</p>

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Prediction of CD8+ T cell infiltration in the tumor microenvironment of HGSOC patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月20日

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  • Jia Mai,
  • Ling Yang,
  • YuXin Chen,
  • XiaoXu Zeng,
  • HongJian Xie,
  • XiaoJuan Liu

摘要

The tumor microenvironment (TME), particularly CD8+ T cell infiltration, critically influences high-grade serous ovarian cancer (HGSOC) progression and treatment response. The development and management of cancer depend heavily on CD8+ T cells. Identifying non-invasive predictors of TME immune status is crucial. We investigated whether clinicopathologic characteristics and peripheral blood parameters could predict CD8+ T infiltration in TME of HGSOC. Two independent cohort were analyzed: (1) A multicenter tissue microarray (TMA) cohort of 105 epithelial ovarian cancer cases revealed that high CD8+ T cell density in tumor parenchyma, stroma, or whole tissue was significantly associated with good prognosis. (2) A retrospective cohort of 95 HGSOC patients from West China Second University Hospital (2016–2020) demonstrated that peripheral blood lymphocytes, globulin (GLB), lactate dehydrogenase (LDH), and low-density lipoprotein (LDL) correlated with CD8+ T cell infiltration in TME. These findings support non-invasive blood markers as predictors of tumor immune status and highlight chemotherapy’s role in enhancing CD8+ T cell recruitment.