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<p>Early stages of age-related macular degeneration (AMD) can lead to a number of visual function deficits, but the patient relevance of these deficits is largely unknown. We therefore investigated how bilateral visual function domains affected by age-related macular degeneration (AMD) are associated with patient-reports. Using data from the cross-sectional part of the MACUSTAR study with 245 individuals with AMD (34 early AMD, 168 intermediate (i) AMD, 43 late AMD), the Vision Impairment in Low Luminance (VILL) questionnaire (subscales: reading, VILL_R; mobility, VILL_M; emotional well-being, VILL_E) and visual function assessments from both eyes (best-corrected and low-luminance visual acuity, BCVA, LLVA; Moorfields acuity, MA; contrast sensitivity, CS) were included. Associations between VILL and visual function data (better and worse eyes defined based on BCVA) were investigated using age- and sex-adjusted regression models. In the overall sample, VILL_R and VILL_M were associated with all functional tests across eyes (p ≤ 0.0389), while VILL_E was associated with MA and CS (p ≤ 0.0302). Regression estimates for BCVA, LLVA, MA and CS in the better-seeing eyes were -2.70, -1.84, -1.83 and 1.08 (VILL_R); -2.71, -1.87, -1.90 and 1.88 (VILL_M), and -0.25, -0.22, -2.15 and 1.57 (VILL_E). In iAMD, CS and MA in the worse-seeing eye were associated with two VILL subscales, respectively (VILL_R and VILL_M; VILL_M and VILL_E, respectively; p ≤ 0.0395), while BCVA and LLVA in the worse-seeing eye were both associated with one VILL subscale (VILL_M; p ≤ 0.0317). CS in the better eye was associated with VILL_M (p = 0.0454). Thus, patient-reported outcomes are associated with visual function assessments in both eyes in people with AMD. Contrast vision seems particularly patient-relevant in iAMD. Our results further support the construct validity of the VILL questionnaire.</p>

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Patient-reported vision impairment in low luminance relates to visual function in age-related macular degeneration: A MACUSTAR study report

  • 期刊论文

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  • 发表日期：

    2025年10月9日

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  • Jan Henrik Terheyden,
  • Charlotte Behning,
  • Hannah M. P. Dunbar,
  • Stephen Poor,
  • Nadia Zakaria,
  • Alison M. Binns,
  • Marlene Saßmannshausen,
  • Sergio Leal,
  • Matthias Schmid,
  • Frank G. Holz,
  • David P. Crabb,
  • Ulrich F. O. Luhmann,
  • Robert P. Finger,
  • H. Agostini,
  • I. D. Aires,
  • L. Altay,
  • R. Atia,
  • F. Bandello,
  • P. G. Basile,
  • J. Batuca,
  • C. Behning,
  • M. Belmouhand,
  • M. Berger,
  • A. Binns,
  • C. J. F. Boon,
  • M. Böttger,
  • J. E. Brazier,
  • C. Carapezzi,
  • J. Carlton,
  • A. Carneiro,
  • A. Charil,
  • R. Coimbra,
  • D. Cosette,
  • M. Cozzi,
  • D. P. Crabb,
  • J. Cunha-Vaz,
  • C. Dahlke,
  • H. Dunbar,
  • S. Esposti,
  • R. P. Finger,
  • E. Fletcher,
  • M. Gutfleisch,
  • F. Hartgers,
  • B. Higgins,
  • J. Hildebrandt,
  • E. Höck,
  • R. Hogg,
  • F. G. Holz,
  • C. B. Hoyng,
  • A. Kilani,
  • J. Krätzschmar,
  • L. Kühlewein,
  • M. Larsen,
  • S. Leal,
  • Y. T. E. Lechanteur,
  • U. F. O. Luhmann,
  • A. Lüning,
  • N. Manivannan,
  • I. Marques,
  • C. Martinho,
  • K. P. Moll,
  • Z. Mulyukov,
  • M. Paques,
  • B. Parodi,
  • M. Parravano,
  • S. Penas,
  • T. Peters,
  • T. Peto,
  • M. Pfau,
  • S. Priglinger,
  • S. Ramamirtham,
  • S. Ribeiro,
  • D. Rowen,
  • G. S. Rubin,
  • J. Sahel,
  • C. Sánchez,
  • O. Sander,
  • M. Saßmannshausen,
  • M. Schmid,
  • S. Schmitz-Valckenberg,
  • J. Siedlecki,
  • R. Silva,
  • E. Souied,
  • G. Staurenghi,
  • J. Tavares,
  • D. J. Taylor,
  • J. H. Terheyden,
  • A. Tufail,
  • P. Valmaggia,
  • M. Varano,
  • A. Wolf,
  • N. Zakaria

摘要

Early stages of age-related macular degeneration (AMD) can lead to a number of visual function deficits, but the patient relevance of these deficits is largely unknown. We therefore investigated how bilateral visual function domains affected by age-related macular degeneration (AMD) are associated with patient-reports. Using data from the cross-sectional part of the MACUSTAR study with 245 individuals with AMD (34 early AMD, 168 intermediate (i) AMD, 43 late AMD), the Vision Impairment in Low Luminance (VILL) questionnaire (subscales: reading, VILL_R; mobility, VILL_M; emotional well-being, VILL_E) and visual function assessments from both eyes (best-corrected and low-luminance visual acuity, BCVA, LLVA; Moorfields acuity, MA; contrast sensitivity, CS) were included. Associations between VILL and visual function data (better and worse eyes defined based on BCVA) were investigated using age- and sex-adjusted regression models. In the overall sample, VILL_R and VILL_M were associated with all functional tests across eyes (p ≤ 0.0389), while VILL_E was associated with MA and CS (p ≤ 0.0302). Regression estimates for BCVA, LLVA, MA and CS in the better-seeing eyes were -2.70, -1.84, -1.83 and 1.08 (VILL_R); -2.71, -1.87, -1.90 and 1.88 (VILL_M), and -0.25, -0.22, -2.15 and 1.57 (VILL_E). In iAMD, CS and MA in the worse-seeing eye were associated with two VILL subscales, respectively (VILL_R and VILL_M; VILL_M and VILL_E, respectively; p ≤ 0.0395), while BCVA and LLVA in the worse-seeing eye were both associated with one VILL subscale (VILL_M; p ≤ 0.0317). CS in the better eye was associated with VILL_M (p = 0.0454). Thus, patient-reported outcomes are associated with visual function assessments in both eyes in people with AMD. Contrast vision seems particularly patient-relevant in iAMD. Our results further support the construct validity of the VILL questionnaire.