Scholarlink

<p>Esophageal squamous cell carcinoma (ESCC) is a major global health issue, with postoperative hospital length of stay (LOS) being a critical factor influencing patient outcomes and healthcare costs. This study evaluates the impact of preoperative albumin-to-fibrinogen ratio (AFR) and albumin-to-D-II aggregates ratio (ADR) on LOS in patients with locally advanced ESCC undergoing neoadjuvant therapy. A retrospective study of 135 patients with locally advanced ESCC who underwent esophagectomy after neoadjuvant therapy (July 2013–November 2020). Demographic, clinical, and preoperative blood data were analyzed. LOS was defined from surgery to discharge. AFR and ADR values were calculated, and ROC curves identified optimal cutoffs. Multivariate Cox proportional hazards models and Kaplan–Meier analysis were used to assess relationships between AFR and LOS. The optimal AFR cutoff was 10.34, demonstrating better predictive accuracy for LOS than ADR. High AFR was associated with significantly shorter LOS. Multivariate analysis revealed high AFR, and cholesterol were linked to shorter stays, while older age and high globulin levels were associated with longer stays. Kaplan–Meier analysis confirmed the relationship. Preoperative AFR is a reliable predictor of LOS in advanced ESCC patients after neoadjuvant therapy, offering potential for improved clinical management and resource allocation.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Preoperative albumin-to-fibrinogen ratio as a predictor of postoperative hospital stay in locally advanced esophageal squamous cell carcinoma after neoadjuvant therapy

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月29日

查看全文
  • Hao Chen,
  • Xuan Huang,
  • Yipeng Chen,
  • Weiming Chen,
  • Xin Yan,
  • Chun Chen,
  • Bin Zheng,
  • Haitang Lin,
  • Hanliang Zhang,
  • Chunyu Zhou,
  • Chi Xu,
  • Zhang Yang

摘要

Esophageal squamous cell carcinoma (ESCC) is a major global health issue, with postoperative hospital length of stay (LOS) being a critical factor influencing patient outcomes and healthcare costs. This study evaluates the impact of preoperative albumin-to-fibrinogen ratio (AFR) and albumin-to-D-II aggregates ratio (ADR) on LOS in patients with locally advanced ESCC undergoing neoadjuvant therapy. A retrospective study of 135 patients with locally advanced ESCC who underwent esophagectomy after neoadjuvant therapy (July 2013–November 2020). Demographic, clinical, and preoperative blood data were analyzed. LOS was defined from surgery to discharge. AFR and ADR values were calculated, and ROC curves identified optimal cutoffs. Multivariate Cox proportional hazards models and Kaplan–Meier analysis were used to assess relationships between AFR and LOS. The optimal AFR cutoff was 10.34, demonstrating better predictive accuracy for LOS than ADR. High AFR was associated with significantly shorter LOS. Multivariate analysis revealed high AFR, and cholesterol were linked to shorter stays, while older age and high globulin levels were associated with longer stays. Kaplan–Meier analysis confirmed the relationship. Preoperative AFR is a reliable predictor of LOS in advanced ESCC patients after neoadjuvant therapy, offering potential for improved clinical management and resource allocation.