Scholarlink

<p>Childhood maltreatment can disrupt brain development, leading to vulnerabilities in white matter (WM) microstructure, compromised brain integrity, and various psychiatric disorders. Among different forms of maltreatment, neglect is the most common; however, limited data exist on its specific impact on the brain. This study utilized diffusion tensor imaging to examine WM microstructure differences between neglected children without other types of maltreatment (Neglect, <i>n</i> = 21) and typically developing controls (TD, <i>n</i> = 106). Additionally, the study explored the relationship between WM microstructure alterations and psychosocial problems observed in neglected children. Neglected children exhibited larger axial diffusion (AD) in regions such as the right corticospinal tract (R.CST), right superior longitudinal fasciculus (R.SLF), and left cingulum (L.CG) compared to typically developing children. Increased AD in the R.CST, L.CG, and R.SLF was associated with conduct problems. These findings suggest that alterations in WM microstructure contributed to behavioral symptoms in neglected children.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

White matter microstructure abnormalities in children experiencing neglect without other forms of maltreatment

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月26日

查看全文
  • Natasha Y.S. Kawata,
  • Takashi X. Fujisawa,
  • Kai Makita,
  • Akiko Yao,
  • Hidehiko Okazawa,
  • Akemi Tomoda

摘要

Childhood maltreatment can disrupt brain development, leading to vulnerabilities in white matter (WM) microstructure, compromised brain integrity, and various psychiatric disorders. Among different forms of maltreatment, neglect is the most common; however, limited data exist on its specific impact on the brain. This study utilized diffusion tensor imaging to examine WM microstructure differences between neglected children without other types of maltreatment (Neglect, n = 21) and typically developing controls (TD, n = 106). Additionally, the study explored the relationship between WM microstructure alterations and psychosocial problems observed in neglected children. Neglected children exhibited larger axial diffusion (AD) in regions such as the right corticospinal tract (R.CST), right superior longitudinal fasciculus (R.SLF), and left cingulum (L.CG) compared to typically developing children. Increased AD in the R.CST, L.CG, and R.SLF was associated with conduct problems. These findings suggest that alterations in WM microstructure contributed to behavioral symptoms in neglected children.