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<p>To evaluate the diagnostic value of plasma D-dimer combined with transvaginal ultrasonography for endometrial carcinoma in postmenopausal women, addressing the increasing incidence in China. This retrospective study analyzed 129 postmenopausal women (July 2021–January 2023) undergoing hysteroscopy, including 61 with endometrial carcinoma (mean age 56.5 ± 6.8&#xa0;years) and 68 with benign lesions (60.2 ± 7.7&#xa0;years). We assessed D-dimer levels, ultrasonographic parameters (endometrial thickness, uterine cavity occupation, blood flow signals), and postmenopausal bleeding. Diagnostic performance was evaluated using ROC curves. Multivariate analysis identified three independent predictors: intracavitary blood flow (OR 60.44, 95% CI 8.25–442.98, <i>p</i> &lt; 0.001), postmenopausal bleeding (OR 5.84, 95% CI 1.82–18.75, <i>p</i> = 0.003), and elevated D-dimer (OR 3.12, 95% CI 1.06–9.22, <i>p</i> = 0.04). The comprehensive model achieved superior diagnostic performance (AUC = 0.920, sensitivity = 88.5%, specificity = 85.3%) compared to any individual parameter. Plasma D-dimer combined with transvaginal ultrasonography and clinical symptoms provides an effective screening approach for postmenopausal endometrial carcinoma, serving as a valuable risk assessment strategy for identifying candidates requiring definitive histopathological examination.</p>

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Clinical value of D-dimer combined with transvaginal ultrasonography in the postmenopausal population with endometrial carcinoma

  • 期刊论文

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  • 发表日期：

    2025年7月28日

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  • Xiaoli Guo,
  • Yun Cheng,
  • Junqiang Du

摘要

To evaluate the diagnostic value of plasma D-dimer combined with transvaginal ultrasonography for endometrial carcinoma in postmenopausal women, addressing the increasing incidence in China. This retrospective study analyzed 129 postmenopausal women (July 2021–January 2023) undergoing hysteroscopy, including 61 with endometrial carcinoma (mean age 56.5 ± 6.8 years) and 68 with benign lesions (60.2 ± 7.7 years). We assessed D-dimer levels, ultrasonographic parameters (endometrial thickness, uterine cavity occupation, blood flow signals), and postmenopausal bleeding. Diagnostic performance was evaluated using ROC curves. Multivariate analysis identified three independent predictors: intracavitary blood flow (OR 60.44, 95% CI 8.25–442.98, p < 0.001), postmenopausal bleeding (OR 5.84, 95% CI 1.82–18.75, p = 0.003), and elevated D-dimer (OR 3.12, 95% CI 1.06–9.22, p = 0.04). The comprehensive model achieved superior diagnostic performance (AUC = 0.920, sensitivity = 88.5%, specificity = 85.3%) compared to any individual parameter. Plasma D-dimer combined with transvaginal ultrasonography and clinical symptoms provides an effective screening approach for postmenopausal endometrial carcinoma, serving as a valuable risk assessment strategy for identifying candidates requiring definitive histopathological examination.