Scholarlink

<p>A new efficient synthesis of TR<sub>β</sub>-selective thyromimetic GC-1 is described. The present strategy employs benzyl substituent as the exclusive protecting group, avoiding side reactions and simplifying the purification process in the last step. This paper reports 62% overall yield in six steps for total synthesis of GC-1 in multi-gram scale. The initial synthetic route is adaptable to analogue design and suitable for the preparation of other natural methylenebisphenols.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

An improved synthesis of TRβ-selective thyromimetic GC-1

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月23日

查看全文
  • Xiaohui Chu,
  • Jinjun Wang,
  • Yanzhong Li

摘要

A new efficient synthesis of TRβ-selective thyromimetic GC-1 is described. The present strategy employs benzyl substituent as the exclusive protecting group, avoiding side reactions and simplifying the purification process in the last step. This paper reports 62% overall yield in six steps for total synthesis of GC-1 in multi-gram scale. The initial synthetic route is adaptable to analogue design and suitable for the preparation of other natural methylenebisphenols.