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<p>This study investigated the causal relationships between cytokines, chemokines, neutrophil-related factors, sleep traits, and CMR-derived cardiovascular phenotypes using two-sample Mendelian randomization (MR) analysis. The primary method employed was inverse variance weighted (IVW) analysis, supplemented with MR-Egger and weighted median analyses. We identified 24 significant associations, excluding the SNP rs2001329 related to sleep duration. Notably, CXCL9 showed a strong association with right ventricular peak atrial filling rate (OR = 587.45), while IL-5 was associated with right ventricular stroke volume (OR = 2.45). IL-7 and IL-18 significantly impacted four CMR-derived phenotypes each. Left ventricular ejection fraction was frequently affected by IL-1β, IL-18, CCL2, CXCL9, and NETs. Sensitivity analyses indicated minimal pleiotropy or heterogeneity except for sleep duration. This research highlights crucial cytokines and chemokines that modulate cardiac function through their relationships with cardiovascular phenotypes.</p>

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Causal relationships between inflammatory mediators, sleep traits, and cardiac magnetic resonance imaging-derived cardiac phenotypes

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月11日

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  • Shuhui Cao,
  • Hongjie Xu,
  • Yangfeng Tang,
  • Zhiyun Xu,
  • Shangyi Yu

摘要

This study investigated the causal relationships between cytokines, chemokines, neutrophil-related factors, sleep traits, and CMR-derived cardiovascular phenotypes using two-sample Mendelian randomization (MR) analysis. The primary method employed was inverse variance weighted (IVW) analysis, supplemented with MR-Egger and weighted median analyses. We identified 24 significant associations, excluding the SNP rs2001329 related to sleep duration. Notably, CXCL9 showed a strong association with right ventricular peak atrial filling rate (OR = 587.45), while IL-5 was associated with right ventricular stroke volume (OR = 2.45). IL-7 and IL-18 significantly impacted four CMR-derived phenotypes each. Left ventricular ejection fraction was frequently affected by IL-1β, IL-18, CCL2, CXCL9, and NETs. Sensitivity analyses indicated minimal pleiotropy or heterogeneity except for sleep duration. This research highlights crucial cytokines and chemokines that modulate cardiac function through their relationships with cardiovascular phenotypes.