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<p>The effects of conjugated equine estrogens (CEE) and 17β-estradiol-based hormone replacement therapy (HRT) on atherosclerosis development remain controversial. Here, we investigated the effects of equilin, a major compound in CEE, and 17β-estradiol on atherosclerosis development in an atherosclerotic mouse model. Female B6.KOR/StmSlc-<i>Apoe</i><sup><i>shl</i></sup> mice were ovariectomized and fed a high-fat diet for 9 and 12&#xa0;weeks (early and late groups, respectively) and then treated with 17β-estradiol or equilin. Atherosclerotic lesions in the aortic arch and brachiocephalic artery (BCA) were assessed at the end of the experimental period. Compared with placebo, equilin and 17β-estradiol significantly inhibited atherosclerotic lesion formation in the aortic arch and BCA in both groups. However, 17β-estradiol had a significantly greater inhibitory effect than equilin in the late group. Although 17β-estradiol significantly inhibited atherosclerosis progression in the aortic root, no significant difference was observed between the equilin and placebo groups. Additionally, compared with equilin, 17β-estradiol significantly inhibited atherosclerotic plaque formation in the aortic root. Moreover, 17β-estradiol exerted a stronger inhibitory effect on atherogenesis than equilin and control. Both 17β-estradiol and equilin protect against atherosclerotic plaque formation in the vascular endothelium, with 17β-estradiol exhibiting a superior effect.</p>

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Effects of 17β-estradiol and equilin on atherosclerosis development in female Apoeshl mice

  • 期刊论文

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  • 发表日期：

    2025年7月10日

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  • Akiyo Kakibuchi,
  • Fumitake Ito,
  • Osamu Takaoka,
  • Nanami Tahara,
  • Mari Kawamata,
  • Kazuya Yabumoto,
  • Akihisa Katayama,
  • Yuko Izumi,
  • Eiko Maeda,
  • Taisuke Mori

摘要

The effects of conjugated equine estrogens (CEE) and 17β-estradiol-based hormone replacement therapy (HRT) on atherosclerosis development remain controversial. Here, we investigated the effects of equilin, a major compound in CEE, and 17β-estradiol on atherosclerosis development in an atherosclerotic mouse model. Female B6.KOR/StmSlc-Apoeshl mice were ovariectomized and fed a high-fat diet for 9 and 12 weeks (early and late groups, respectively) and then treated with 17β-estradiol or equilin. Atherosclerotic lesions in the aortic arch and brachiocephalic artery (BCA) were assessed at the end of the experimental period. Compared with placebo, equilin and 17β-estradiol significantly inhibited atherosclerotic lesion formation in the aortic arch and BCA in both groups. However, 17β-estradiol had a significantly greater inhibitory effect than equilin in the late group. Although 17β-estradiol significantly inhibited atherosclerosis progression in the aortic root, no significant difference was observed between the equilin and placebo groups. Additionally, compared with equilin, 17β-estradiol significantly inhibited atherosclerotic plaque formation in the aortic root. Moreover, 17β-estradiol exerted a stronger inhibitory effect on atherogenesis than equilin and control. Both 17β-estradiol and equilin protect against atherosclerotic plaque formation in the vascular endothelium, with 17β-estradiol exhibiting a superior effect.