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<p>Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway. Our study delineates YEATS2’s oncogenic functions in HCC and its potential as a prognostic and predictive biomarker. Through comprehensive in vitro and bioinformatics analyses, we reveal that YEATS2 promotes cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Additionally, YEATS2 modulates the tumor immune microenvironment and predicts response to immunotherapies and chemotherapies. YEATS2’s serum stability suggests its utility as a non-invasive biomarker for personalized HCC treatment.</p>

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The value of acetylation reader YEATS2 in hepatocellular carcinoma management

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月29日

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  • Yongjie Shi,
  • Qiwen Xiao,
  • Weichun Xiao,
  • Jiale Kang,
  • Qiang Zhou,
  • Hongyun Jia,
  • Yimei Chen,
  • Sicong Huang

摘要

Hepatocellular carcinoma (HCC) is frequently associated with Yeats-domain containing 2 (YEATS2) overexpression, which enhances tumor progression via the PI3K/AKT pathway. Our study delineates YEATS2’s oncogenic functions in HCC and its potential as a prognostic and predictive biomarker. Through comprehensive in vitro and bioinformatics analyses, we reveal that YEATS2 promotes cell proliferation, invasion, and epithelial-mesenchymal transition (EMT). Additionally, YEATS2 modulates the tumor immune microenvironment and predicts response to immunotherapies and chemotherapies. YEATS2’s serum stability suggests its utility as a non-invasive biomarker for personalized HCC treatment.