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<p>In this study, we report the synthesis and photothermal evaluation of polymer-functionalized molybdenum disulfide (MoS₂) nanoplatforms with distinct morphologies; three-dimensional (3D) nanoflowers (MNF) and two-dimensional (2D) nanorods (MNR), tailored for targeted drug delivery applications. The MoS₂ nanostructures were synthesized via a hydrothermal route by modulating the sulfur precursor, yielding morphology-dependent growth. The resulting nanostructures were subsequently functionalized with polyethylene glycol (PEG) and polyethyleneimine (PEI), producing MNF@PEG@PEI (MFPP) and MNR@PEG@PEI (MRPP) platforms. Comprehensive characterization via FESEM, FTIR, and XRD confirmed the formation of distinct morphologies, effective polymer functionalization through amine and carboxyl groups, and the coexistence of 1T/2H MoS₂ phases. Photothermal properties were evaluated under 808&#xa0;nm NIR laser irradiation. MFPP demonstrated a photothermal conversion efficiency of 46.86%, significantly higher than the 19.94% observed for MRPP. Moreover, functionalization enhanced the temperature elevation in MNF from 10.2&#xa0;°C to 14.5&#xa0;°C, whereas MNR showed minimal improvement (5.0&#xa0;°C to 5.6&#xa0;°C). This performance enhancement in MFPP is attributed to its porous, multi-layered architecture, which facilitates higher NIR absorption via multiple internal reflections and active defect sites. These findings highlight MFPP as a promising candidate for photothermal and photoacoustic imaging-guided drug delivery, reinforcing the importance of morphological and surface-engineering strategies in designing next-generation MoS₂-based nanocarriers for cancer therapy.</p>

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Morphology-driven photothermal performance of polymer-functionalized mos₂ nanoplatforms for targeted therapeutic applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月18日

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  • Ashima Sharma,
  • Dinesh Bhalothia,
  • Raviraj Vankayala,
  • Ashima Bagaria

摘要

In this study, we report the synthesis and photothermal evaluation of polymer-functionalized molybdenum disulfide (MoS₂) nanoplatforms with distinct morphologies; three-dimensional (3D) nanoflowers (MNF) and two-dimensional (2D) nanorods (MNR), tailored for targeted drug delivery applications. The MoS₂ nanostructures were synthesized via a hydrothermal route by modulating the sulfur precursor, yielding morphology-dependent growth. The resulting nanostructures were subsequently functionalized with polyethylene glycol (PEG) and polyethyleneimine (PEI), producing MNF@PEG@PEI (MFPP) and MNR@PEG@PEI (MRPP) platforms. Comprehensive characterization via FESEM, FTIR, and XRD confirmed the formation of distinct morphologies, effective polymer functionalization through amine and carboxyl groups, and the coexistence of 1T/2H MoS₂ phases. Photothermal properties were evaluated under 808 nm NIR laser irradiation. MFPP demonstrated a photothermal conversion efficiency of 46.86%, significantly higher than the 19.94% observed for MRPP. Moreover, functionalization enhanced the temperature elevation in MNF from 10.2 °C to 14.5 °C, whereas MNR showed minimal improvement (5.0 °C to 5.6 °C). This performance enhancement in MFPP is attributed to its porous, multi-layered architecture, which facilitates higher NIR absorption via multiple internal reflections and active defect sites. These findings highlight MFPP as a promising candidate for photothermal and photoacoustic imaging-guided drug delivery, reinforcing the importance of morphological and surface-engineering strategies in designing next-generation MoS₂-based nanocarriers for cancer therapy.