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<p>Researchers have recently grown interested in utilizing plant extracts as effective reducing agents for the eco-friendly synthesis of nanoparticles. The present investigation involved the preparation of Iraqi onion extract (<i>Allium cepa</i>), which was further utilized as a reducing agent for the biosynthesis of Fe<sub>3</sub>O<sub>4</sub>-nanoparticles (NPs). Characterization of nanoparticles was conducted using UV-visible spectroscopy, TEM, XRD, FT-IR, FESEM, and EDS analyses. The in vitro cytotoxicity was assessed in MDCK-SIAT cells utilizing the MTT assay, while the antiviral efficacy was examined with the neuraminidase assay kit MAK12. Antibacterial efficacy was examined against <i>S. aureus</i> and <i>E.</i> coli utilizing a disk-diffusion methodology. The DPPH assay was employed to evaluate antioxidant activity. The impact of <i>A. cepa</i> extract and Fe<sub>3</sub>O<sub>4</sub>-NPs on phagocytic cell activity was evaluated. Our findings demonstrated the production of solid, crystalline, semi-spherical Fe<sub>3</sub>O<sub>4</sub> measuring 36 ± 1.23&#xa0;nm, exhibiting significant antibacterial, antiviral, and antioxidant properties. <i>A. cepa</i> extract and Fe<sub>3</sub>O<sub>4</sub>-NPs can augment the phagocytic activity of phagocytic cells by elevating the formation of reactive oxygen species. In conclusion, Onion peel extract is a superior option for synthesizing Fe<sub>3</sub>O<sub>4</sub>-NPs, which may be employed in many therapeutic applications in the future.</p>

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Insights into the pharmaceutical properties of green fabricated Iron oxide nanoparticles

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月29日

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  • H. N. K. AL-Salman,
  • Qutaiba A. Qasim,
  • Basil A. Abbas,
  • Adel J. Hussein,
  • Falah Hassan Shari,
  • Majid S. Jabir,
  • Mansour K. Gatasheh,
  • Ammar AL-Farga,
  • Hayder Adnan Fawzi

摘要

Researchers have recently grown interested in utilizing plant extracts as effective reducing agents for the eco-friendly synthesis of nanoparticles. The present investigation involved the preparation of Iraqi onion extract (Allium cepa), which was further utilized as a reducing agent for the biosynthesis of Fe3O4-nanoparticles (NPs). Characterization of nanoparticles was conducted using UV-visible spectroscopy, TEM, XRD, FT-IR, FESEM, and EDS analyses. The in vitro cytotoxicity was assessed in MDCK-SIAT cells utilizing the MTT assay, while the antiviral efficacy was examined with the neuraminidase assay kit MAK12. Antibacterial efficacy was examined against S. aureus and E. coli utilizing a disk-diffusion methodology. The DPPH assay was employed to evaluate antioxidant activity. The impact of A. cepa extract and Fe3O4-NPs on phagocytic cell activity was evaluated. Our findings demonstrated the production of solid, crystalline, semi-spherical Fe3O4 measuring 36 ± 1.23 nm, exhibiting significant antibacterial, antiviral, and antioxidant properties. A. cepa extract and Fe3O4-NPs can augment the phagocytic activity of phagocytic cells by elevating the formation of reactive oxygen species. In conclusion, Onion peel extract is a superior option for synthesizing Fe3O4-NPs, which may be employed in many therapeutic applications in the future.