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<p>Tenofovir is an antiviral drug that prevents the replication of AIDS and hepatitis B viruses. To minimize the harmful side effects of the drug on the body, it is essential to determine its precise concentration in the blood. Fluorescence spectroscopy is a cost-effective and highly sensitive method for detecting drugs like tenofovir. In this study, carbon nitride (g-C<sub>3</sub>N<sub>4</sub>), a unique form of carbon known for its exceptional stability, high quantum efficiency and specific surface area, was used to create a C<sub>3</sub>N<sub>4</sub>/Fe/Cu sensor. The g-C<sub>3</sub>N<sub>4</sub>/Fe/Cu sensor was characterized using SEM, UV-VIS, PL, EDX, mapping and FT-IR methods. The influencing factors of C<sub>3</sub>N<sub>4</sub>/Fe/Cu response, such as pH, analyte concentration and temperature, were optimized during the experiments. Various concentrations of tenofovir were prepared in water and added to g-C<sub>3</sub>N<sub>4</sub>/Fe/Cu. The fluorescence intensity of the resulting solutions was analyzed using PL analysis at a wavelength of 463&#xa0;nm under optimal conditions. The results confirmed the identification of tenofovir in pharmaceutical capsules within the concentration range of 5.0-700.0 µM using g-C<sub>3</sub>N<sub>4</sub>/Cu/Fe. A strong linear relationship with an R<sup>2</sup> = 0.9304 and a LOD = 3.2 µM (signal-to-noise = 3) was achieved. Therefore, g-C<sub>3</sub>N<sub>4</sub>/Fe/Cu is recommended for tenofovir drug assay.</p>

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Investigating the performance of the fluorescent sensor g-C3N4/Fe/Cu in detecting the Tenofovir drug

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Nafiseh Hajian Afarani,
  • Fatemeh Keshavarzi,
  • Kahin Shahanipour,
  • Seyed Amir Zarei

摘要

Tenofovir is an antiviral drug that prevents the replication of AIDS and hepatitis B viruses. To minimize the harmful side effects of the drug on the body, it is essential to determine its precise concentration in the blood. Fluorescence spectroscopy is a cost-effective and highly sensitive method for detecting drugs like tenofovir. In this study, carbon nitride (g-C3N4), a unique form of carbon known for its exceptional stability, high quantum efficiency and specific surface area, was used to create a C3N4/Fe/Cu sensor. The g-C3N4/Fe/Cu sensor was characterized using SEM, UV-VIS, PL, EDX, mapping and FT-IR methods. The influencing factors of C3N4/Fe/Cu response, such as pH, analyte concentration and temperature, were optimized during the experiments. Various concentrations of tenofovir were prepared in water and added to g-C3N4/Fe/Cu. The fluorescence intensity of the resulting solutions was analyzed using PL analysis at a wavelength of 463 nm under optimal conditions. The results confirmed the identification of tenofovir in pharmaceutical capsules within the concentration range of 5.0-700.0 µM using g-C3N4/Cu/Fe. A strong linear relationship with an R2 = 0.9304 and a LOD = 3.2 µM (signal-to-noise = 3) was achieved. Therefore, g-C3N4/Fe/Cu is recommended for tenofovir drug assay.