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<p>Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. This study aimed to determine preoperative prognostic factors in patients undergoing surgery for metastatic spinal tumors associated with lung cancer. This prospective registry study included 74 patients diagnosed and operated with metastatic spine tumors derived from lung cancer in 39 high-volume cancer centers. We examined the postoperative survival period and the preoperative factors related to postoperative survival time. We conducted univariate and multivariate Cox regression analyses to determine preoperative prognostic factors. The mean postoperative survival period was 343 days. Multivariate Cox regression analysis revealed a higher feeding score of vitality index, indications for molecularly targeted therapy, and a higher mobility score of Barthel index as independent factors associated with postoperative survival time in metastatic spinal tumors derived from lung cancer. Patients with indications for molecular-targeted therapy and good vitality exhibited longer survival. These results may help in surgical selection for patients with metastatic spinal tumors derived from lung cancer.</p>

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Survival days of patients with metastatic spinal tumors of lung cancer requiring surgery: a prospective multicenter study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月6日

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  • Takuya Takahashi,
  • Takashi Hirai,
  • Yuki Shiratani,
  • Akinobu Suzuki,
  • Kenichiro Kakutani,
  • Satoshi Kato,
  • Hiroyuki Tominaga,
  • Hirokazu Inoue,
  • Hirokatsu Sawada,
  • Norihiko Takegami,
  • Kazuo Nakanishi,
  • Hideaki Nakajima,
  • Masayuki Ishihara,
  • Tsutomu Oshigiri,
  • Toru Funayama,
  • Takuya Iimura,
  • Shinji Tanishima,
  • Hiroaki Nakashima,
  • Daisuke Yamabe,
  • Ko Hashimoto,
  • Koji Uotani,
  • Masahiro Funaba,
  • Narihito Nagoshi,
  • Kazu Kobayakawa,
  • Toshitaka Yoshii,
  • Kazuyuki Watanabe,
  • Toshio Nakamae,
  • Takashi Kaito,
  • Gen Inoue,
  • Shiro Imagama,
  • Kota Watanabe,
  • Takeo Furuya

摘要

Surgery for metastatic spinal tumors has improved postoperative activities of daily living. A few studies reported on prognostic factors assessed in large multicenter prospective studies for metastatic spinal tumors of lung cancer origin. This study aimed to determine preoperative prognostic factors in patients undergoing surgery for metastatic spinal tumors associated with lung cancer. This prospective registry study included 74 patients diagnosed and operated with metastatic spine tumors derived from lung cancer in 39 high-volume cancer centers. We examined the postoperative survival period and the preoperative factors related to postoperative survival time. We conducted univariate and multivariate Cox regression analyses to determine preoperative prognostic factors. The mean postoperative survival period was 343 days. Multivariate Cox regression analysis revealed a higher feeding score of vitality index, indications for molecularly targeted therapy, and a higher mobility score of Barthel index as independent factors associated with postoperative survival time in metastatic spinal tumors derived from lung cancer. Patients with indications for molecular-targeted therapy and good vitality exhibited longer survival. These results may help in surgical selection for patients with metastatic spinal tumors derived from lung cancer.