Scholarlink

<p>N-Methyl-D-aspartate receptors (NMDAR) are essential for synaptic plasticity and cognitive function, making their modulation a promising strategy for treating disorders like schizophrenia and cognitive impairment. However, methods to selectively modulate NMDAR activity in the lesion’s nucleus of the central nervous system remain limited. In this study, using whole-cell patch-clamp recordings, we demonstrated that frequency-specific (42.5 THz) terahertz irradiation significantly enhanced both the frequency and amplitude of NMDAR-mediated miniature excitatory postsynaptic currents (mEPSCs), a response closely linked to Ca²⁺ currents. The mechanism is elucidated via molecular dynamics (MD) simulations, revealing that 42.5 THz irradiation effectively alters the free energy landscape of Ca²⁺ permeating through the NMDAR channel. Specifically, THz photons resonated with key carboxyl groups at the Ca²⁺ binding site, leading to an increase in Ca²⁺ permeability and consequently enhanced mEPSCs. These findings suggest a novel physical therapy approach for treating cognitive deficits and neurological disorders associated with impaired NMDAR function.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Spatiotemporal terahertz modulation enhances NMDAR-mediated miniature EPSCs

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月1日

查看全文
  • Shaolei Jiang,
  • Yuan Zhong,
  • Peng Chen,
  • Anqi Wang,
  • Junquan Zhu,
  • Yangmei Li,
  • Zhi Zhu

摘要

N-Methyl-D-aspartate receptors (NMDAR) are essential for synaptic plasticity and cognitive function, making their modulation a promising strategy for treating disorders like schizophrenia and cognitive impairment. However, methods to selectively modulate NMDAR activity in the lesion’s nucleus of the central nervous system remain limited. In this study, using whole-cell patch-clamp recordings, we demonstrated that frequency-specific (42.5 THz) terahertz irradiation significantly enhanced both the frequency and amplitude of NMDAR-mediated miniature excitatory postsynaptic currents (mEPSCs), a response closely linked to Ca²⁺ currents. The mechanism is elucidated via molecular dynamics (MD) simulations, revealing that 42.5 THz irradiation effectively alters the free energy landscape of Ca²⁺ permeating through the NMDAR channel. Specifically, THz photons resonated with key carboxyl groups at the Ca²⁺ binding site, leading to an increase in Ca²⁺ permeability and consequently enhanced mEPSCs. These findings suggest a novel physical therapy approach for treating cognitive deficits and neurological disorders associated with impaired NMDAR function.