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<p>This study investigated the effect of total joint arthroplasty (TJA) on arterial stiffness in patients with severe osteoarthritis (OA) compared to non-OA controls. A prospective cohort of 70 severe OA patients undergoing TJA (mean age 62 ± 7) and 82 age- and sex-matched controls without OA was followed over seven years. Aortic pulse wave velocity (aPWV), augmentation index (AIx), and central and peripheral haemodynamic parameters were measured using applanation tonometry (Sphygmocor) at baseline and follow-up. At baseline, the aPWV was significantly higher in the TJA group (<i>p</i> = 0.023). Over seven years, aPWV increased significantly in the control group, eliminating the between-group difference (9.3 ± 0.3&#xa0;m/s in TJA vs. 9.3 ± 0.2&#xa0;m/s in controls, <i>p</i> = 0.939). AIx was initially similar between groups,&#xa0;but was significantly lower in the TJA group at follow-up (<i>p</i> = 0.005). The increase in central diastolic blood pressure was also significantly smaller in the TJA group (<i>p</i> = 0.008). These results indicate that TJA may slow the progression of arterial stiffness and reduce central haemodynamic changes in severe OA patients compared to the general population.</p>

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The impact of total joint arthroplasty on arterial stiffness in osteoarthritis patients: a 7-year prospective cohort study (CAMERA study)

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Elin Kersti Sõber-Williams,
  • Kadri Loorits,
  • Jaak Kals,
  • Aare Märtson,
  • Pärt Prommik,
  • Kaspar Tootsi

摘要

This study investigated the effect of total joint arthroplasty (TJA) on arterial stiffness in patients with severe osteoarthritis (OA) compared to non-OA controls. A prospective cohort of 70 severe OA patients undergoing TJA (mean age 62 ± 7) and 82 age- and sex-matched controls without OA was followed over seven years. Aortic pulse wave velocity (aPWV), augmentation index (AIx), and central and peripheral haemodynamic parameters were measured using applanation tonometry (Sphygmocor) at baseline and follow-up. At baseline, the aPWV was significantly higher in the TJA group (p = 0.023). Over seven years, aPWV increased significantly in the control group, eliminating the between-group difference (9.3 ± 0.3 m/s in TJA vs. 9.3 ± 0.2 m/s in controls, p = 0.939). AIx was initially similar between groups, but was significantly lower in the TJA group at follow-up (p = 0.005). The increase in central diastolic blood pressure was also significantly smaller in the TJA group (p = 0.008). These results indicate that TJA may slow the progression of arterial stiffness and reduce central haemodynamic changes in severe OA patients compared to the general population.