<p>Limited studies have evaluated the influence of redox-related metals on the Alzheimer´s brain. We determined 15 metals in 241 human brain samples obtained from five biobanks. We examined the levels of metals in the frontal cortex (CTX) and the basal ganglia (BG) of Alzheimer´s brains of different stages, ranging from Braak stages I and II to Braak stages V and VI. Imbalances measured metals in the Alzheimer´s brain metallome of different Braak stages and different regions compared to controls, and associations between metals and Braak stages were estimated by the Kruskal-Wallis Test and Spearman correlations, respectively. We observed higher levels of Mn, Cu, Mo, and Se and lower levels of Co in Alzheimer´s CTX compared to the controls, and higher levels of V and Cr and lower levels of Co in BG. Metals may differ in Braak stages across different human brain regions. Although the etiology of Alzheimer´s disease (AD) remains unclear, the amyloid cascade hypothesis is the most widely accepted. Thus, the accumulation of amyloid beta (Aβ₄₂) in the brain would be the primary event in the cascade that leads to p-tau hyperphosphorylation, neurofibrillary tangle (NFT) formation, synaptic dysfunction, and neuronal death.</p>