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<p>Early diagnosis of hepatocellular carcinoma (HCC) is essential in improving survival, creating a need for new markers in the early diagnosis and surveillance of HCC. This study aims to investigate the prediction of the GALAD score, which consists of gender, age, AFP, AFP-L3, and DCP, in the diagnosis of HCC in cirrhotic patients with normal AFP levels. GALAD scores were determined in 100 patients with cirrhosis and normal AFP in a tertiary center. The role of the GALAD score in the surveillance of HCC was investigated prospectively. 100 cirrhotic patients (59 male, mean age 60.4 ± 13.6 years) participated. GALAD score was higher in cases with HCC (GALAD = -0.66 in cases with HCC, and − 3.10 in cases without HCC, <i>p</i> &lt; 0.001). The cut-off value of the GALAD score in the diagnosis of HCC was found to be -1.93 according to ROC analysis (AUC of 0.798, 95% CI: 70.5–89.1, sensitivity = 71%, specificity = 71%). In regression analysis, the risk of developing HCC was 3.4 times higher in patients with a GALAD score ≥ -1.93. The GALAD score is an important marker for the surveillance of HCC in cirrhotic patients with normal AFP.</p>

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The role of GALAD score in the surveillance of hepatocellular carcinoma

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Zülal İstemihan,
  • İbrahim Volkan Şenkal,
  • Dilan Karaca,
  • Kanan Nuriyev,
  • Aynura Rustamzade,
  • Sezen Genç Uluçeçen,
  • Gizem Dağcı,
  • Mehmet Akif Yağlı,
  • Asım Gurbanov,
  • Pelin Telli,
  • Bilger Çavuş,
  • Aslı Çifcibaşı Örmeci,
  • Filiz Akyüz,
  • Kadir Demir,
  • Fatih Beşışık,
  • Sabahattin Kaymakoğlu

摘要

Early diagnosis of hepatocellular carcinoma (HCC) is essential in improving survival, creating a need for new markers in the early diagnosis and surveillance of HCC. This study aims to investigate the prediction of the GALAD score, which consists of gender, age, AFP, AFP-L3, and DCP, in the diagnosis of HCC in cirrhotic patients with normal AFP levels. GALAD scores were determined in 100 patients with cirrhosis and normal AFP in a tertiary center. The role of the GALAD score in the surveillance of HCC was investigated prospectively. 100 cirrhotic patients (59 male, mean age 60.4 ± 13.6 years) participated. GALAD score was higher in cases with HCC (GALAD = -0.66 in cases with HCC, and − 3.10 in cases without HCC, p < 0.001). The cut-off value of the GALAD score in the diagnosis of HCC was found to be -1.93 according to ROC analysis (AUC of 0.798, 95% CI: 70.5–89.1, sensitivity = 71%, specificity = 71%). In regression analysis, the risk of developing HCC was 3.4 times higher in patients with a GALAD score ≥ -1.93. The GALAD score is an important marker for the surveillance of HCC in cirrhotic patients with normal AFP.