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<p>Doxorubicin (DOX) is an effective anticancer drug, but its clinical application is limited due to its severe adverse effects on multiple organs and tissues, particularly cardiotoxicity. Studies suggest that metformin and Coenzyme Q10 (CoQ10) may help reduce DOX-induced cardiotoxicity. This study investigated the individual and combined effects of metformin and CoQ10 on DOX-induced cardiotoxicity in rats. 36 male Wistar rats were divided into six groups consisting of N_C, C_Dox (25&#xa0;mg/kg DOX), C_(Met + Q10) (200&#xa0;mg/kg metformin + 10&#xa0;mg/kg CoQ10), T_Met (200&#xa0;mg/kg metformin + 25&#xa0;mg/kg DOX), T_Q10 (10&#xa0;mg/kg CoQ10 + 25&#xa0;mg/kg DOX), and T_(Met + Q10) (200&#xa0;mg/kg metformin + 10&#xa0;mg/kg CoQ10 + 25&#xa0;mg/kg DOX). DOX administration significantly elevated serum CK-MB, LDH (<i>P</i> &lt; 0.05), and tissue MDA (<i>P</i> &lt; 0.001). It also significantly decreased TAC, CAT, GPx (<i>P</i> &lt; 0.001), and SOD (<i>P</i> &lt; 0.01) in heart tissues. Treatment with metformin and CoQ10 significantly restored the biochemical parameters both in the serum and tissue samples and ameliorated the histopathological damage caused by DOX. In conclusion, the combination of metformin and CoQ10 exerted antioxidant and cardioprotective effects against DOX-induced cardiotoxicity.</p>

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Combined effects of metformin and coenzyme Q10 on doxorubicin-induced cardiotoxicity in male wistar rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Faraz Mahdizadeh,
  • Aliakbar Fazaeli,
  • Shiva Rahimi,
  • Masoud Ojarudi,
  • Pouria Sobhi,
  • Mohammad Bahrami,
  • Lotfollah Rezagholizadeh

摘要

Doxorubicin (DOX) is an effective anticancer drug, but its clinical application is limited due to its severe adverse effects on multiple organs and tissues, particularly cardiotoxicity. Studies suggest that metformin and Coenzyme Q10 (CoQ10) may help reduce DOX-induced cardiotoxicity. This study investigated the individual and combined effects of metformin and CoQ10 on DOX-induced cardiotoxicity in rats. 36 male Wistar rats were divided into six groups consisting of N_C, C_Dox (25 mg/kg DOX), C_(Met + Q10) (200 mg/kg metformin + 10 mg/kg CoQ10), T_Met (200 mg/kg metformin + 25 mg/kg DOX), T_Q10 (10 mg/kg CoQ10 + 25 mg/kg DOX), and T_(Met + Q10) (200 mg/kg metformin + 10 mg/kg CoQ10 + 25 mg/kg DOX). DOX administration significantly elevated serum CK-MB, LDH (P < 0.05), and tissue MDA (P < 0.001). It also significantly decreased TAC, CAT, GPx (P < 0.001), and SOD (P < 0.01) in heart tissues. Treatment with metformin and CoQ10 significantly restored the biochemical parameters both in the serum and tissue samples and ameliorated the histopathological damage caused by DOX. In conclusion, the combination of metformin and CoQ10 exerted antioxidant and cardioprotective effects against DOX-induced cardiotoxicity.