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<p>Recent literature gives different results on morbidity and mortality after COVID-19 hospitalization as compared to Influenza. In this registry-based study in Austria, we compared the short- and long-term outcomes after COVID-19 or Influenza hospitalization and associations with their baseline medication load. Data were provided on children and adolescents hospitalized with COVID-19 (sample size: 1061) in the years 2020 and 2021 or with Influenza in 2016–2021 (sample size: 2781) as well as on matched controls from the Austrian population (10,626 controls for COVID-19 and 27,634 for Influenza). The median follow-up time was 430&#xa0;days in the COVID-19 and 1221&#xa0;days in the Influenza group. Hospitalized children were more likely to have a larger disease burden as compared to the general population. Influenza patients were observed to be generally younger with a larger percentage of polypharmacy than those with COVID-19. No significant difference in the time to hospital discharge was found between Influenza and COVID-19 patients (HR 1.22 [95% CI 0.97–1.55], <i>p</i> = 0.093). The risk for readmission was significantly higher for Influenza (HR 1.23 [95% CI 1.03–1.47], <i>p</i> = 0.021). In-hospital mortality (COVID-19: 0.94%; Influenza: 0.22%) and 1-year mortality (COVID-19: 1.13%; Influenza: 0.31%) were observed to be higher in COVID-19 patients but severe events were generally rare. The findings suggest that COVID-19 should not generally be considered a milder disease than Influenza.</p>

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Short and long-term outcomes of children and adolescents hospitalized with COVID-19 or influenza: results of the AUTCOV study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月2日

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  • Christine Wagenlechner,
  • Ralph Wendt,
  • Berthold Reichardt,
  • Michael Mildner,
  • Julia Mascherbauer,
  • Clemens Aigner,
  • Johann Auer,
  • Hendrik Jan Ankersmit,
  • Alexandra Christine Graf

摘要

Recent literature gives different results on morbidity and mortality after COVID-19 hospitalization as compared to Influenza. In this registry-based study in Austria, we compared the short- and long-term outcomes after COVID-19 or Influenza hospitalization and associations with their baseline medication load. Data were provided on children and adolescents hospitalized with COVID-19 (sample size: 1061) in the years 2020 and 2021 or with Influenza in 2016–2021 (sample size: 2781) as well as on matched controls from the Austrian population (10,626 controls for COVID-19 and 27,634 for Influenza). The median follow-up time was 430 days in the COVID-19 and 1221 days in the Influenza group. Hospitalized children were more likely to have a larger disease burden as compared to the general population. Influenza patients were observed to be generally younger with a larger percentage of polypharmacy than those with COVID-19. No significant difference in the time to hospital discharge was found between Influenza and COVID-19 patients (HR 1.22 [95% CI 0.97–1.55], p = 0.093). The risk for readmission was significantly higher for Influenza (HR 1.23 [95% CI 1.03–1.47], p = 0.021). In-hospital mortality (COVID-19: 0.94%; Influenza: 0.22%) and 1-year mortality (COVID-19: 1.13%; Influenza: 0.31%) were observed to be higher in COVID-19 patients but severe events were generally rare. The findings suggest that COVID-19 should not generally be considered a milder disease than Influenza.