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<p>Chemotherapy, used to treat hydatid cysts, can cause problems due to various side effects. Consequently, there is growing interest in non-chemical alternatives, such as medicinal plant extracts, as potential new treatments for hydatid cysts. This study investigated the protoscolicidal activity of green tea (<i>Camellia sinensis</i>) and lavender (<i>Lavandula angustifolia</i>) extracts at different concentrations and exposure times under laboratory conditions. Protoscolices were collected aseptically from the liver of sheep infected with hydatid cysts and exposed to three concentrations of <i>C. sinensis</i> and <i>L. angustifolia</i> extracts (10, 25, and 50&#xa0;mg/mL) for 10, 20, 30, and 60&#xa0;min. The viability of protoscolices was assessed using 0.1% eosin staining. The results showed that <i>C. sinensis</i> and <i>L. angustifolia</i> extracts at a concentration of 50&#xa0;mg/mL effectively eliminated all protoscolices after 20&#xa0;min. The scolicidal effects of <i>C. sinensis</i> and <i>L. angustifolia</i> were significant compared to the control groups. Furthermore, the results showed that these plant extracts have high protoscolicidal activity. However, further studies are needed to evaluate their <i>in vivo</i> effectiveness for treating hydatid cysts in humans and herbivorous animals.</p>

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In vitro evaluation of the susceptibility of Echinococcus granulosus hydatid cysts to lavender and green tea extracts

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Seyed Mohammad Mehdizadeh,
  • Farnaz Malekifard,
  • Bijan Esmaeilnejad

摘要

Chemotherapy, used to treat hydatid cysts, can cause problems due to various side effects. Consequently, there is growing interest in non-chemical alternatives, such as medicinal plant extracts, as potential new treatments for hydatid cysts. This study investigated the protoscolicidal activity of green tea (Camellia sinensis) and lavender (Lavandula angustifolia) extracts at different concentrations and exposure times under laboratory conditions. Protoscolices were collected aseptically from the liver of sheep infected with hydatid cysts and exposed to three concentrations of C. sinensis and L. angustifolia extracts (10, 25, and 50 mg/mL) for 10, 20, 30, and 60 min. The viability of protoscolices was assessed using 0.1% eosin staining. The results showed that C. sinensis and L. angustifolia extracts at a concentration of 50 mg/mL effectively eliminated all protoscolices after 20 min. The scolicidal effects of C. sinensis and L. angustifolia were significant compared to the control groups. Furthermore, the results showed that these plant extracts have high protoscolicidal activity. However, further studies are needed to evaluate their in vivo effectiveness for treating hydatid cysts in humans and herbivorous animals.