Scholarlink

<p><i>Pseudomonas aeruginosa (P. aeruginosa)</i> is a predominant etiological agent of nosocomial infections. This research examined the efficacy of rutin encapsulated in chitosan nanoparticles (Rut-CS) in inhibiting the proliferation of multidrug-resistant <i>P. aeruginosa</i> and diminishing biofilm formation. SEM, DLS and FTIR analyzed the nanoparticles to ascertain their shape. The antibacterial activity was evaluated using agar well diffusion. The findings indicated that Rut-CS nanoparticles had considerable antibacterial efficacy and substantially reduced the expression of critical biofilm-associated genes, <i>lasR</i> and <i>AlgD</i>. The Rut-CS nanoparticles exhibited no toxicity to human dermal fibroblast (HDF) cells at the minimal inhibitory dose. The data indicate that Rut-CS nanoparticles may serve as a viable technique to address highly resistant P. aeruginosa infections, facilitating novel antibacterial research methodologies.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The antimicrobial efficacy of rutin encapsulated chitosan versus multidrug-resistant Pseudomonas aeruginosa

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月1日

查看全文
  • Helia Ramezani,
  • Hossein Sazegar,
  • Leila Rouhi

摘要

Pseudomonas aeruginosa (P. aeruginosa) is a predominant etiological agent of nosocomial infections. This research examined the efficacy of rutin encapsulated in chitosan nanoparticles (Rut-CS) in inhibiting the proliferation of multidrug-resistant P. aeruginosa and diminishing biofilm formation. SEM, DLS and FTIR analyzed the nanoparticles to ascertain their shape. The antibacterial activity was evaluated using agar well diffusion. The findings indicated that Rut-CS nanoparticles had considerable antibacterial efficacy and substantially reduced the expression of critical biofilm-associated genes, lasR and AlgD. The Rut-CS nanoparticles exhibited no toxicity to human dermal fibroblast (HDF) cells at the minimal inhibitory dose. The data indicate that Rut-CS nanoparticles may serve as a viable technique to address highly resistant P. aeruginosa infections, facilitating novel antibacterial research methodologies.