Scholarlink

<p>This study aimed to determine the key risk factors affecting sentinel lymph node (SLN) metastasis and to help improve the selection of appropriate candidates for SLN biopsy (SLNB). A total of 2143 cases that underwent SLNB were included. Multivariate analysis included the statistically significant parameters in univariate analysis and revealed the independent risk factors for SLN metastasis: age younger than 40&#xa0;years old, central tumor location, tumor larger than 3&#xa0;cm, round-shaped and cortex-thickened axillary lymph node examined by ultrasound, lymphovascular invasion (LVI), and histological classification of invasive breast carcinoma of no special type (IBC-NST) and invasive micropapillary carcinoma (IMPC). The most powerful prognostic factor for SLN metastasis is IMPC (<i>P</i> &lt; 0.001), which increases more than 11 times the risk of SLN positivity. The distance between the tumor and nipple of ≤ 1&#xa0;cm, LVI, and age younger than 40&#xa0;years old are also with <i>P</i> value &lt; 0.001. The identification of predictors for SLN metastases based on clinicopathological characteristics could guide the SLNB practice conveniently, especially in less developed areas. Patients with theses revealed adverse features should undergo SLNB with deliberation to avoid a second surgery, particularly when multiple risk factors exist.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Risk factors of sentinel lymph node metastasis in early-stage invasive breast cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月1日

查看全文
  • Tong Wang,
  • Yilin Wang,
  • Yilin Xu,
  • Qi Cui

摘要

This study aimed to determine the key risk factors affecting sentinel lymph node (SLN) metastasis and to help improve the selection of appropriate candidates for SLN biopsy (SLNB). A total of 2143 cases that underwent SLNB were included. Multivariate analysis included the statistically significant parameters in univariate analysis and revealed the independent risk factors for SLN metastasis: age younger than 40 years old, central tumor location, tumor larger than 3 cm, round-shaped and cortex-thickened axillary lymph node examined by ultrasound, lymphovascular invasion (LVI), and histological classification of invasive breast carcinoma of no special type (IBC-NST) and invasive micropapillary carcinoma (IMPC). The most powerful prognostic factor for SLN metastasis is IMPC (P < 0.001), which increases more than 11 times the risk of SLN positivity. The distance between the tumor and nipple of ≤ 1 cm, LVI, and age younger than 40 years old are also with P value < 0.001. The identification of predictors for SLN metastases based on clinicopathological characteristics could guide the SLNB practice conveniently, especially in less developed areas. Patients with theses revealed adverse features should undergo SLNB with deliberation to avoid a second surgery, particularly when multiple risk factors exist.