<p>Previous studies have documented hypertension remission following bariatric surgeries and other gastrointestinal surgeries, but the impact of esophagectomy on hypertension remains unclear. This study assesses whether esophagectomy induces hypertension remission in esophageal cancer patients and identifies influencing factors. This retrospective study included 66 esophageal cancer patients with hypertension who underwent esophagectomy (2017–2020). Patients were classified into remission and non-remission groups based on postoperative hypertension status. Preoperative and six-month postoperative data (age, weight, BMI, hypertension duration, metabolic indicators) were analyzed. Independent predictors of remission were identified via binary logistic regression. At six months post-esophagectomy, 34.8% achieved complete remission, 30.4% showed improvement, and 34.8% had no remission. Significant reductions in weight, BMI, systolic blood pressure (p &lt; 0.001), and LDL (p = 0.04), along with increased HDL levels (p &lt; 0.001), were observed. Patients in the remission group were younger (p = 0.028), had shorter hypertension duration (p = 0.013), and lower HDL levels (p = 0.031). Age, %TWL, and hypertension duration were independent predictors of remission. Esophagectomy in esophageal cancer patients facilitates weight loss, improves lipid profiles, and promotes hypertension remission, primarily through postoperative weight loss, particularly in younger patients with shorter hypertension duration. </p>