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<p>Bacterial infections are a major global health concern due to increasing antibiotic resistance and high mortality rates. Medicinal plants, such as <i>Satureja khuzestanica</i> essential oil (EO), offer a promising natural alternative for combating resistant pathogens. The bioactive composition of <i>S. khuzestanica</i> EO was analyzed using gas chromatography-mass spectrometry (GC-MS). Alginate/CarboxyMethyl Cellulose (CMC) and alginate nanoparticle/CMC hydrogels incorporating EO were formulated. Rheological properties were evaluated, and encapsulation efficiency was confirmed using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR). The antibacterial efficacy of these formulations was assessed against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. GC-MS identified carvacrol, thymol, gamma-terpinene, ortho-cymene, and limonene as the major bioactive compounds. Rheological analysis revealed that all formulations exhibited shear-thinning behavior, following the Carreau-Yasuda model. Notably, the alginate nanoparticle/CMC hydrogel containing EO (H-AlgNP/CMC-EO) demonstrated significantly enhanced antibacterial activity, achieving complete (100%) inhibition of <i>S. aureus</i> and <i>P. aeruginosa</i> growth, surpassing conventional hydrogels. The superior antimicrobial performance of H-AlgNP/CMC-EO highlights its potential as a novel therapeutic approach for combating bacterial infections, warranting further investigation in biomedical applications.</p>

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Antibacterial activity of a conventional hydrogel and a nanoparticle based hydrogel containing Satureja khuzestanica essential oil

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Khashayar Saboori,
  • Maedeh Nassira,
  • Mojdeh Safari,
  • Najmeh Namdar,
  • Zahra Montaseri,
  • Mahmoud Osanloo

摘要

Bacterial infections are a major global health concern due to increasing antibiotic resistance and high mortality rates. Medicinal plants, such as Satureja khuzestanica essential oil (EO), offer a promising natural alternative for combating resistant pathogens. The bioactive composition of S. khuzestanica EO was analyzed using gas chromatography-mass spectrometry (GC-MS). Alginate/CarboxyMethyl Cellulose (CMC) and alginate nanoparticle/CMC hydrogels incorporating EO were formulated. Rheological properties were evaluated, and encapsulation efficiency was confirmed using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR). The antibacterial efficacy of these formulations was assessed against Staphylococcus aureus and Pseudomonas aeruginosa. GC-MS identified carvacrol, thymol, gamma-terpinene, ortho-cymene, and limonene as the major bioactive compounds. Rheological analysis revealed that all formulations exhibited shear-thinning behavior, following the Carreau-Yasuda model. Notably, the alginate nanoparticle/CMC hydrogel containing EO (H-AlgNP/CMC-EO) demonstrated significantly enhanced antibacterial activity, achieving complete (100%) inhibition of S. aureus and P. aeruginosa growth, surpassing conventional hydrogels. The superior antimicrobial performance of H-AlgNP/CMC-EO highlights its potential as a novel therapeutic approach for combating bacterial infections, warranting further investigation in biomedical applications.