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<p>Breast cancer is a leading health concern in Saudi Arabia, characterized by unique demographic and clinical profiles. This study analyzed breast cancer cases at King Fahad Specialist Hospital-Dammam (KFSH-D), focusing on age at diagnosis, disease stage, histological type, and hormonal receptor status. A retrospective cohort study included 5,954 breast cancer patients diagnosed between 2006 and 2022 from the KFSH-D database. Data were extracted via a Real-World Evidence Digital Platform adhering to international standards. Statistical analyses included descriptive statistics, Chi-square tests, t-tests, incidence and mortality rate calculations, survival analysis, and predictive modeling for future incidence trends. The cohort had a mean age at diagnosis of 49 years (SD = 12.0), with most patients aged 40–59 years. Over 99% were female and predominantly Saudi nationals. Approximately two-thirds presented with locally advanced disease, with invasive ductal carcinoma being the most common type (81%). Al Ahsa region accounted for 31% of referral cases. Hormonal receptor status showed 59% HER2-negative, 61% ER-positive, and 56% PR-positive. Predictive modeling forecasted an 80% increase in new cases by 2028, with incidence rates expected to double. This study highlights a younger median age at diagnosis and a high prevalence of late-stage disease. These findings underscore the urgent need for improved screening programs, targeted public health interventions, and better healthcare access in Saudi Arabia.</p>

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A comprehensive epidemiological analysis of breast cancer in the Eastern Province of Saudi Arabia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Hani Almohanna,
  • Fahad Almsned,
  • Hulayel Alharbi,
  • Norah Al Dossary,
  • Amjad Alrasheed,
  • Reem Alzayer,
  • Kholoud Alwosaibai

摘要

Breast cancer is a leading health concern in Saudi Arabia, characterized by unique demographic and clinical profiles. This study analyzed breast cancer cases at King Fahad Specialist Hospital-Dammam (KFSH-D), focusing on age at diagnosis, disease stage, histological type, and hormonal receptor status. A retrospective cohort study included 5,954 breast cancer patients diagnosed between 2006 and 2022 from the KFSH-D database. Data were extracted via a Real-World Evidence Digital Platform adhering to international standards. Statistical analyses included descriptive statistics, Chi-square tests, t-tests, incidence and mortality rate calculations, survival analysis, and predictive modeling for future incidence trends. The cohort had a mean age at diagnosis of 49 years (SD = 12.0), with most patients aged 40–59 years. Over 99% were female and predominantly Saudi nationals. Approximately two-thirds presented with locally advanced disease, with invasive ductal carcinoma being the most common type (81%). Al Ahsa region accounted for 31% of referral cases. Hormonal receptor status showed 59% HER2-negative, 61% ER-positive, and 56% PR-positive. Predictive modeling forecasted an 80% increase in new cases by 2028, with incidence rates expected to double. This study highlights a younger median age at diagnosis and a high prevalence of late-stage disease. These findings underscore the urgent need for improved screening programs, targeted public health interventions, and better healthcare access in Saudi Arabia.