Scholarlink

<p>Vision deterioration caused by natural aging have a detrimental impact on an individual’s quality of life, which has become a serious problem as the world’s population is aging rapidly. Rodents are the commonly used animal species to investigate the physiological aging process or to identify possible therapeutic targets. However, due to anatomical differences and their genetic distance to humans, translation of findings is sometimes complicated. In the present study, as a step toward aging study in vision using non-human primate marmosets, we examined the eyes of aged marmosets non-invasively. We found that the retinal response deteriorated along with the retinal structure in aged marmosets and the retinal peripheral region was more susceptible to aging. Moreover, the expression of the oxidative stress biomarker 4-HNE was increased in the serum of aged marmosets although no significant correlation was found between 4-HNE levels and the retinal thickness. Our study demonstrated that marmosets offer a promising translational model for the research of age-related vision declination.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Age-related decline in retinal function in marmosets

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月1日

查看全文
  • Takahiko Noro,
  • Xiaoli Guo,
  • Rika Kikuchi,
  • Kenya Sato,
  • Kazuhiko Namekata,
  • Youichi Shinozaki,
  • Chikako Harada,
  • Terumi Yurimoto,
  • Nanako Hashimoto,
  • Keiko Moriya-Ito,
  • Tadashi Nakano,
  • Erika Sasaki,
  • Takayuki Harada

摘要

Vision deterioration caused by natural aging have a detrimental impact on an individual’s quality of life, which has become a serious problem as the world’s population is aging rapidly. Rodents are the commonly used animal species to investigate the physiological aging process or to identify possible therapeutic targets. However, due to anatomical differences and their genetic distance to humans, translation of findings is sometimes complicated. In the present study, as a step toward aging study in vision using non-human primate marmosets, we examined the eyes of aged marmosets non-invasively. We found that the retinal response deteriorated along with the retinal structure in aged marmosets and the retinal peripheral region was more susceptible to aging. Moreover, the expression of the oxidative stress biomarker 4-HNE was increased in the serum of aged marmosets although no significant correlation was found between 4-HNE levels and the retinal thickness. Our study demonstrated that marmosets offer a promising translational model for the research of age-related vision declination.