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<p>Optimal nutrition and physical activity are vital for enhancing physical performance and preventing metabolic diseases like obesity. Recently, interest has grown in long-term fasting, particularly water-only fasting, which involves no food intake and unlimited water consumption. Our study investigated the effects of 8&#xa0;days of water-only fasting combined with aerobic exercise in 13 middle-aged men, focusing on metabolic, hormonal, and immune changes. Results showed that fasting had a more significant impact than exercise, leading to changes in glucose, uric acid, IGF-1, IGF-2, GH, leptin, and cortisol, improved total antioxidant status (TAS), and reduced lipid peroxidation. While exercise enhanced the effects of fasting on triglycerides, insulin, GH, TAS, PerOX, and IL-6, changes in total protein and lactate were solely due to exercise. Overall, combining fasting and exercise led to a metabolic shift from carbohydrates to fatty acids and hormonal adaptations to stress. These results, although derived from a small group of patients, offer a promising outlook for further research into the effects of fasting combined with physical activity on health and weight maintenance.</p>

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Metabolic and hormonal effects of an 8 days water only fasting combined with exercise in middle aged men

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月2日

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  • Karol Pilis,
  • Urszula Godlewska,
  • Anna Pilis,
  • Krzysztof Stec,
  • Patrycja Dolibog,
  • Marek Kruszewski,
  • Adrianna Kosior-Lara,
  • Romanbek Kalmatov,
  • Wiesław Pilis,
  • Sławomir Letkiewicz

摘要

Optimal nutrition and physical activity are vital for enhancing physical performance and preventing metabolic diseases like obesity. Recently, interest has grown in long-term fasting, particularly water-only fasting, which involves no food intake and unlimited water consumption. Our study investigated the effects of 8 days of water-only fasting combined with aerobic exercise in 13 middle-aged men, focusing on metabolic, hormonal, and immune changes. Results showed that fasting had a more significant impact than exercise, leading to changes in glucose, uric acid, IGF-1, IGF-2, GH, leptin, and cortisol, improved total antioxidant status (TAS), and reduced lipid peroxidation. While exercise enhanced the effects of fasting on triglycerides, insulin, GH, TAS, PerOX, and IL-6, changes in total protein and lactate were solely due to exercise. Overall, combining fasting and exercise led to a metabolic shift from carbohydrates to fatty acids and hormonal adaptations to stress. These results, although derived from a small group of patients, offer a promising outlook for further research into the effects of fasting combined with physical activity on health and weight maintenance.