Scholarlink

<p>The thermal behavior of crystalline and amorphous lovastatin was studied using advanced thermal analysis, including the Quantum Design Physical Property Measurement System and Differential Scanning Calorimetry. Equilibrium lines for liquid and solid states were determined from experimental heat capacity values, allowing for the calculation of state functions. The Kauzmann temperature (<i>T</i><sub>K</sub>) was estimated based on enthalpy and entropy as a function of temperature. Physical ageing studies were conducted at 10&#xa0;°C for various durations, from 15&#xa0;min up to 72&#xa0;h and fictive temperatures were determined for the aged samples. Quantitative thermal analysis provided essential thermodynamic data for both the crystalline and amorphous phases of lovastatin.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Heat capacity and thermodynamic functions of crystalline and amorphous forms of Lovastatin

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年7月2日

查看全文
  • Maria Brycka,
  • Agata Olszewska,
  • Natalie Parkinson,
  • Christopher Hoban,
  • Anna Czerniecka-Kubicka,
  • Marek Pyda,
  • Brian F. Woodfield,
  • Marcin Skotnicki

摘要

The thermal behavior of crystalline and amorphous lovastatin was studied using advanced thermal analysis, including the Quantum Design Physical Property Measurement System and Differential Scanning Calorimetry. Equilibrium lines for liquid and solid states were determined from experimental heat capacity values, allowing for the calculation of state functions. The Kauzmann temperature (TK) was estimated based on enthalpy and entropy as a function of temperature. Physical ageing studies were conducted at 10 °C for various durations, from 15 min up to 72 h and fictive temperatures were determined for the aged samples. Quantitative thermal analysis provided essential thermodynamic data for both the crystalline and amorphous phases of lovastatin.