<p>Cardiovascular and cerebrovascular diseases are critical public health challenges influenced by environmental and meteorological factors. Understanding the association between these factors and disease incidence can provide valuable insights for disease prevention and control.This study analyzed data from Anshun City, western Guizhou, collected between January 2018 and December 2022. A Distributed Lag Non-linear Model (DLNM) was employed to evaluate the lagged and non-linear effects of meteorological variables (e.g., temperature, precipitation, wind speed) and air pollutants (e.g., PM2.5, SO2) on the incidence of cardiovascular and cerebrovascular diseases. Covariates such as seasonality and time trends were included to adjust for confounding effects.The results revealed significant associations between meteorological factors, air pollution, and disease incidence. Increased precipitation and SO2 concentrations significantly elevated the risk of cardiovascular and cerebrovascular diseases, particularly at a lag of 25–30 days (e.g., RR for SO2 = 1.19, 95% CI: 1.10–1.28). Conversely, higher average and maximum wind speeds demonstrated a protective effect (e.g., RR for maximum wind speed = 0.70, 95% CI: 0.62–0.78). Seasonal patterns and temperature variations further influenced disease incidence.These findings highlight the complex interactions between meteorological factors and air pollution in influencing cardiovascular and cerebrovascular disease risk. The study provides evidence for targeted public health interventions and emphasizes the importance of incorporating meteorological and environmental data into disease prevention strategies.</p>