<p>Children are particularly vulnerable to the toxic effects of environmental exposure to heavy metals and metalloids (HM/MTs), which can impact red blood cells (RBCs) and platelets. This study aimed to evaluate the relationship between urinary levels of 19 HM/MTs and RBCs and platelet-related hematologic parameters in school-aged children residing in the central western state of Colima, Mexico. A cross-sectional pilot biomonitoring study was conducted, and 91 participants were enrolled. Multiple linear regression models were used to calculate regression coefficients (<InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="41598_2025_3410_Article_IEq1.gif" Format="GIF" Height="17" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:\beta\:\)</EquationSource> </InlineEquation>) and 95% confidence intervals. After adjusting for sex, age, nutritional status, and locality of residence, tin was found to be negatively correlated with red cell distribution width (<InlineEquation ID="IEq2"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="41598_2025_3410_Article_IEq1.gif" Format="GIF" Height="17" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:\beta\:\)</EquationSource> </InlineEquation> = − 0.06, 95% CI − 0.11 to − 0.01). Additionally, each unit increase in urinary lead levels was associated with a 0.6% increase in mean corpuscular hemoglobin (<InlineEquation ID="IEq3"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="41598_2025_3410_Article_IEq1.gif" Format="GIF" Height="17" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:\beta\:\)</EquationSource> </InlineEquation> = 0.006, 95% CI 0.002 to 0.010). Similarly, each unit increase in tellurium levels was associated with a 55% increase in mean platelet volume (<InlineEquation ID="IEq4"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="41598_2025_3410_Article_IEq1.gif" Format="GIF" Height="17" Rendition="HTML" Resolution="72" Type="Linedraw" Width="15" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:\beta\:\)</EquationSource> </InlineEquation> = 0.55, 95% CI 0.08 to 1.02). These results suggest that environmental exposure to HM/MTs may be related to alterations in some of the evaluated hematologic parameters in the analyzed school-aged children. Further research, including larger sample sizes and longitudinal studies, is needed to reduce environmental health risks in this vulnerable population.</p>

Hemoglobin and mean platelet volume abnormalities in children exposed to heavy metals and metalloids in a pilot biomonitoring study

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2025年8月8日

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Oliver Mendoza-Cano,
Mónica Ríos‐Silva,
Irma Elizabeth Gonzalez-Curiel,
Arlette A. Camacho-delaCruz,
María Fernanda Romo-García,
Jaime Alberto Bricio-Barrios,
Herguin Benjamin Cuevas-Arellano,
Ana Luz Quintanilla‐Montoya,
Miguel A. Martínez-Preciado,
Pedro Rincón-Avalos,
Ángel Gabriel Hilerio-López,
Juan Manuel Uribe-Ramos,
Verónica Benites-Godinez,
Efrén Murillo‐Zamora

摘要

Children are particularly vulnerable to the toxic effects of environmental exposure to heavy metals and metalloids (HM/MTs), which can impact red blood cells (RBCs) and platelets. This study aimed to evaluate the relationship between urinary levels of 19 HM/MTs and RBCs and platelet-related hematologic parameters in school-aged children residing in the central western state of Colima, Mexico. A cross-sectional pilot biomonitoring study was conducted, and 91 participants were enrolled. Multiple linear regression models were used to calculate regression coefficients ( \(\:\beta\:\) ) and 95% confidence intervals. After adjusting for sex, age, nutritional status, and locality of residence, tin was found to be negatively correlated with red cell distribution width ( \(\:\beta\:\) = − 0.06, 95% CI − 0.11 to − 0.01). Additionally, each unit increase in urinary lead levels was associated with a 0.6% increase in mean corpuscular hemoglobin ( \(\:\beta\:\) = 0.006, 95% CI 0.002 to 0.010). Similarly, each unit increase in tellurium levels was associated with a 55% increase in mean platelet volume ( \(\:\beta\:\) = 0.55, 95% CI 0.08 to 1.02). These results suggest that environmental exposure to HM/MTs may be related to alterations in some of the evaluated hematologic parameters in the analyzed school-aged children. Further research, including larger sample sizes and longitudinal studies, is needed to reduce environmental health risks in this vulnerable population.