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<p>The genetic factors influencing human longevity have long been a subject of curiosity, linking ancient historical records with modern genomic research. This study seeks to identify key genetic contributors to lifespan by integrating genome-wide association studies (GWAS) with functional annotations across multiple biological databases. Among our findings,&#xa0;APOE emerged as one of the most prominent gene, with the rs7412-C variant showing a strong association with reduced lifespan due to its widely distributed across global populations. Additionally, we observed that rs449647-A and rs405509-T were more frequently found in regions with longer life expectancies, such as Asia, and were less common in African populations, suggesting a possible genetic influence on regional lifespan variations. These findings provide a basis for future research into the genetic mechanisms underlying aging and may contribute to the development of strategies to promote healthy aging.</p>

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Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年7月1日

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  • Rahmat Dani Satria,
  • Usi Sukorini,
  • Mohammad Hendra Setia Lesmana,
  • Lalu Muhammad Irham,
  • Wirawan Adikusuma,
  • Hegaria Rahmawati,
  • Nur Imma Fatimah Harahap,
  • Pranindya Rinastiti,
  • Donytra Arby Wardhana,
  • Osman Sianipar,
  • Gisca Ajeng Widya Ninggar,
  • Zaenal Muttaqien Sofro,
  • Nova Yuli Prasetyo Budi,
  • Josephine Diony Nanda,
  • Faizul Hasan,
  • Tri Budi W. Rahardjo,
  • Chiou-Feng Lin

摘要

The genetic factors influencing human longevity have long been a subject of curiosity, linking ancient historical records with modern genomic research. This study seeks to identify key genetic contributors to lifespan by integrating genome-wide association studies (GWAS) with functional annotations across multiple biological databases. Among our findings, APOE emerged as one of the most prominent gene, with the rs7412-C variant showing a strong association with reduced lifespan due to its widely distributed across global populations. Additionally, we observed that rs449647-A and rs405509-T were more frequently found in regions with longer life expectancies, such as Asia, and were less common in African populations, suggesting a possible genetic influence on regional lifespan variations. These findings provide a basis for future research into the genetic mechanisms underlying aging and may contribute to the development of strategies to promote healthy aging.