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<p>This study evaluated the functional relevance of relative ellipsoid zone reflectivity (rEZR) on spectral-domain optical coherence tomography as a structural biomarker for retinal integrity, focusing on its association with retinal function. Participants with age-related macular degeneration (AMD) and controls from the MACUSTAR study underwent functional testing, including mesopic fundus-controlled perimetry, best-corrected visual acuity, low-luminance visual acuity, low-luminance deficit, Moorfields Acuity Test, and Pelli-Robson contrast sensitivity, along with spectral-domain optical coherence tomography imaging. Structural and functional data were analyzed globally and spatially aligned for topographic analysis. Linear-mixed effects models, adjusted for age, sex, and eccentricity of the rEZR, assessed associations between rEZR and functional metrics. A total of 275 eyes (early AMD, n = 34; intermediate AMD, n = 152; late AMD, n = 36; controls, n = 53) from 275 participants (mean ± standard deviation age: 71.1 ± 7.2&#xa0;years; 63.3% female) were included. In global analyses, rEZR was associated with the mean average threshold in mesopic fundus-controlled perimetry (coefficient estimate 0.0492, 95% confidence interval 0.0190–0.0794, p = 0.0015), low-luminance visual acuity (coefficient estimate −&#xa0;0.0015, 95% confidence interval −&#xa0;0.0026 to −&#xa0;0.0004, p = 0.0092), Moorfields Acuity Test (coefficient estimate 0.0092, 95% confidence interval −&#xa0;0.0022 to −&#xa0;0.0001, p = 0.0285), and Pelli-Robson contrast sensitivity (coefficient estimate 0.0030, 95% confidence interval 0.0015–0.0045, p = 0.0001). Topographic analysis further revealed an association of rEZR with mesopic retinal sensitivity (coefficient estimate 0.0065, 95% confidence interval 0.0026–0.0104, p &lt; 0.0001). Higher outer retinal reflectivity is linked to better retinal function in AMD and controls, supporting its potential as a biomarker for retinal integrity and function.</p>

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Ellipsoid zone reflectivity as a functional imaging biomarker for age-related macular degeneration: a MACUSTAR study report

  • 期刊论文

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  • 发表日期：

    2025年6月20日

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  • Yannick N. Liermann,
  • Charlotte Behning,
  • Ben Isselmann,
  • Matthias Schmid,
  • Hannah M. P. Dunbar,
  • Ulrich F. O. Luhmann,
  • Robert P. Finger,
  • Steffen Schmitz-Valckenberg,
  • Frank G. Holz,
  • Maximilian Pfau,
  • Chi D. Luu,
  • Marlene Saßmannshausen,
  • Sarah Thiele,
  • H. Agostini,
  • L. Altay,
  • R. Atia,
  • F. Bandello,
  • P. G. Basile,
  • C. Behning,
  • M. Belmouhand,
  • M. Berger,
  • A. Binns,
  • C. J. F. Boon,
  • M. Böttger,
  • C. Bouchet,
  • J. E. Brazier,
  • T. Butt,
  • C. Carapezzi,
  • J. Carlton,
  • A. Carneiro,
  • A. Charil,
  • R. Coimbra,
  • M. Cozzi,
  • D. P. Crabb,
  • J. Cunha-Vaz,
  • C. Dahlke,
  • L. de Sisternes,
  • H. Dunbar,
  • R. P. Finger,
  • E. Fletcher,
  • H. Floyd,
  • C. Francisco,
  • M. Gutfleisch,
  • R. Hogg,
  • F. G. Holz,
  • C. B. Hoyng,
  • A. Kilani,
  • J. Krätzschmar,
  • L. Kühlewein,
  • M. Larsen,
  • S. Leal,
  • Y. T. E. Lechanteur,
  • M. Liew,
  • U. F. O. Luhmann,
  • A. Lüning,
  • I. Marques,
  • C. Martinho,
  • A. Miliu,
  • G. Montesano,
  • Z. Mulyukov,
  • M. Paques,
  • B. Parodi,
  • M. Parravano,
  • S. Penas,
  • T. Peters,
  • T. Peto,
  • M. Pfau,
  • S. Priglinger,
  • D. Rowen,
  • G. S. Rubin,
  • J. Sahel,
  • C. Sánchez,
  • O. Sander,
  • M. Saßmannshausen,
  • M. Schmid,
  • S. Schmitz-Valckenberg,
  • H. Schrinner-Fenske,
  • J. Siedlecki,
  • R. Silva,
  • A. Skelly,
  • E. Souied,
  • G. Staurenghi,
  • L. Stöhr,
  • D. J. Taylor,
  • J. H. Terheyden,
  • S. Thiele,
  • A. Tufail,
  • M. Varano,
  • L. Vieweg,
  • A. Wolf,
  • N. Zakaria

摘要

This study evaluated the functional relevance of relative ellipsoid zone reflectivity (rEZR) on spectral-domain optical coherence tomography as a structural biomarker for retinal integrity, focusing on its association with retinal function. Participants with age-related macular degeneration (AMD) and controls from the MACUSTAR study underwent functional testing, including mesopic fundus-controlled perimetry, best-corrected visual acuity, low-luminance visual acuity, low-luminance deficit, Moorfields Acuity Test, and Pelli-Robson contrast sensitivity, along with spectral-domain optical coherence tomography imaging. Structural and functional data were analyzed globally and spatially aligned for topographic analysis. Linear-mixed effects models, adjusted for age, sex, and eccentricity of the rEZR, assessed associations between rEZR and functional metrics. A total of 275 eyes (early AMD, n = 34; intermediate AMD, n = 152; late AMD, n = 36; controls, n = 53) from 275 participants (mean ± standard deviation age: 71.1 ± 7.2 years; 63.3% female) were included. In global analyses, rEZR was associated with the mean average threshold in mesopic fundus-controlled perimetry (coefficient estimate 0.0492, 95% confidence interval 0.0190–0.0794, p = 0.0015), low-luminance visual acuity (coefficient estimate − 0.0015, 95% confidence interval − 0.0026 to − 0.0004, p = 0.0092), Moorfields Acuity Test (coefficient estimate 0.0092, 95% confidence interval − 0.0022 to − 0.0001, p = 0.0285), and Pelli-Robson contrast sensitivity (coefficient estimate 0.0030, 95% confidence interval 0.0015–0.0045, p = 0.0001). Topographic analysis further revealed an association of rEZR with mesopic retinal sensitivity (coefficient estimate 0.0065, 95% confidence interval 0.0026–0.0104, p < 0.0001). Higher outer retinal reflectivity is linked to better retinal function in AMD and controls, supporting its potential as a biomarker for retinal integrity and function.