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<p>The addition of zinc oxide (ZnO) to mineral trioxide aggregate (MTA) has been shown to prevent tooth discoloration; however, its biological effects remain unclear. This study aimed to evaluate the pulpal responses to MTA containing 5% ZnO in full pulpotomy of dogs’ teeth. Forty caries-free premolars from mixed-breed dogs were subjected to full pulpotomy. Exposed pulpal tissues were randomly capped with either Angelus MTA (MTA) or Angelus MTA mixed with 5% ZnO (MTA + ZnO) (<i>n</i> = 20 each). After 4 weeks, the teeth were extracted, processed for histological evaluation, and stained with hematoxylin and eosin. Tissue response data were analyzed using the Mann-Whitney U test at a 95% significance level. The incidence, thickness, and continuity of hard-tissue bridge formation were significantly lower in the MTA + ZnO group (<i>p</i> = 0.007, <i>p</i> = 0.001, and <i>p</i> = 0.002, respectively). Most samples in both groups exhibited no inflammatory cells, and none showed signs of necrosis. Incorporating ZnO into Angelus MTA compromised the quantity and quality of hard-tissue bridge formation following full pulpotomy in dogs’ premolars.</p>

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Pulpal responses to mineral trioxide aggregate with and without zinc oxide addition in mature canine teeth after full pulpotomy

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月7日

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  • Behnam Bolhari,
  • Neda Kardouni Khouzestani,
  • Hadi Assadian,
  • Saeed Farzad-Mohajeri,
  • Mohammad Mehdi Dehghan,
  • Soheil Niavarzi,
  • Behnam Dorost,
  • Venkateshbabu Nagendrababu,
  • Henry F. Duncan,
  • Artak Heboyan,
  • Antonio Signore,
  • Stefano Benedicenti

摘要

The addition of zinc oxide (ZnO) to mineral trioxide aggregate (MTA) has been shown to prevent tooth discoloration; however, its biological effects remain unclear. This study aimed to evaluate the pulpal responses to MTA containing 5% ZnO in full pulpotomy of dogs’ teeth. Forty caries-free premolars from mixed-breed dogs were subjected to full pulpotomy. Exposed pulpal tissues were randomly capped with either Angelus MTA (MTA) or Angelus MTA mixed with 5% ZnO (MTA + ZnO) (n = 20 each). After 4 weeks, the teeth were extracted, processed for histological evaluation, and stained with hematoxylin and eosin. Tissue response data were analyzed using the Mann-Whitney U test at a 95% significance level. The incidence, thickness, and continuity of hard-tissue bridge formation were significantly lower in the MTA + ZnO group (p = 0.007, p = 0.001, and p = 0.002, respectively). Most samples in both groups exhibited no inflammatory cells, and none showed signs of necrosis. Incorporating ZnO into Angelus MTA compromised the quantity and quality of hard-tissue bridge formation following full pulpotomy in dogs’ premolars.