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<p>The growing resistance to antimicrobials, partly due to the ability to form biofilms, poses a challenge for developing new antimicrobial agents. This study assessed the antimicrobial and antibiofilm activity of <i>Hypericum brasiliense</i> extract, Japonicin, and Uliginosin-B against clinical isolates of <i>S. pseudintermedius</i> and <i>S. coagulans</i> from dogs. The minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) were determined. In vitro antibiofilm activity was evaluated and showed promising results in young (6&#xa0;h) and mature (24&#xa0;h) biofilms. <i>S. pseudintermedius</i> and <i>S. coagulans</i> were highly sensitive to all tested substances. All tested isolates exhibited low MIC and MBC values, particularly for Uliginosin-B. Japonicin demonstrated higher MIC and MBC values. The analysis of antibiofilm activity revealed inhibition of biofilm formation and even disruption of pre-formed biofilms at various concentrations, including sub-inhibitory ones. <i>H. brasiliense</i> and its fractions exhibited antimicrobial and antibiofilm activity, offering promising prospects for treating infections caused by biofilm-forming bacteria.</p>

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Antimicrobial and anti-biofilm activity of Hypericum brasiliense extract and its fractions on Staphylococcus of canine origin

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月26日

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  • Yasmim de M. Assumpção,
  • Lialyz S. P. Andre,
  • Izabel M. Teixeira,
  • Carolina O. da Fonseca,
  • Francisco P. Machado,
  • Tainara A. N. Ribeiro,
  • Renata F. A. Pereira,
  • Daniela Sachs,
  • Leandro M. Rocha,
  • Bruno Penna

摘要

The growing resistance to antimicrobials, partly due to the ability to form biofilms, poses a challenge for developing new antimicrobial agents. This study assessed the antimicrobial and antibiofilm activity of Hypericum brasiliense extract, Japonicin, and Uliginosin-B against clinical isolates of S. pseudintermedius and S. coagulans from dogs. The minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) were determined. In vitro antibiofilm activity was evaluated and showed promising results in young (6 h) and mature (24 h) biofilms. S. pseudintermedius and S. coagulans were highly sensitive to all tested substances. All tested isolates exhibited low MIC and MBC values, particularly for Uliginosin-B. Japonicin demonstrated higher MIC and MBC values. The analysis of antibiofilm activity revealed inhibition of biofilm formation and even disruption of pre-formed biofilms at various concentrations, including sub-inhibitory ones. H. brasiliense and its fractions exhibited antimicrobial and antibiofilm activity, offering promising prospects for treating infections caused by biofilm-forming bacteria.