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<p>Respiratory depression is a side effect of anesthetics. Treatment with specific antagonists or respiratory stimulants can reverse respiratory depression caused by anesthetics; however, they also interfere with the sedative effects of anesthetics. Previous studies have suggested that tandospirone may ameliorate respiratory depression without affecting the sedative effects of anesthetics. Therefore, we evaluated whether tandospirone (0.1–8&#xa0;mg/kg) ameliorates respiratory depression in a rat model under anesthesia. The protein kinase A redistribution method was used to determine whether tandospirone activates α<sub>2a/2c</sub> and µ receptors. The effects of tandospirone (10 µM) on α<sub>1</sub>β<sub>2</sub>γ<sub>2</sub> and α<sub>4</sub>β<sub>2</sub>δ GABA receptor current modulation were explored by two-electrode voltage clamping. Prophylactic tandospirone administration reduced respiratory depression caused by anesthetics in rats. Tandospirone (0.1–8&#xa0;mg/kg) increased SaO<sub>2</sub> in rats treated with fentanyl (80&#xa0;µg/kg) or midazolam (80&#xa0;mg/kg) (<i>P</i> &lt; 0.05). The ability of tandospirone to prevent respiratory depression was inhibited by the 5-hydroxytryptamine (5-HT)<sub>1&#xa0;A</sub> receptor antagonist WAY100635 (1&#xa0;mg/kg) (<i>P</i> &lt; 0.05). Co-administration of tandospirone with dexmedetomidine or fentanyl did not affect α<sub>2a/2c</sub> or µ receptors activation. Tandospirone (10 µM) did not affect α<sub>1</sub>β<sub>2</sub>γ<sub>2</sub> and α<sub>4</sub>β<sub>2</sub>δ GABA receptor modulation (<i>P &lt;</i> 0.05). Overall, tandospirone ameliorated respiratory depression caused by anesthetics in rats through 5-HT<sub>1A</sub> receptor activation.</p>

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Tandospirone prevents anesthetic-induced respiratory depression through 5-HT1A receptor activation in rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年1月3日

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  • Meng-ran Song,
  • Ming-zhi Huang,
  • Wei-jie Tao,
  • Zheng Yong,
  • Rui-bin Su

摘要

Respiratory depression is a side effect of anesthetics. Treatment with specific antagonists or respiratory stimulants can reverse respiratory depression caused by anesthetics; however, they also interfere with the sedative effects of anesthetics. Previous studies have suggested that tandospirone may ameliorate respiratory depression without affecting the sedative effects of anesthetics. Therefore, we evaluated whether tandospirone (0.1–8 mg/kg) ameliorates respiratory depression in a rat model under anesthesia. The protein kinase A redistribution method was used to determine whether tandospirone activates α2a/2c and µ receptors. The effects of tandospirone (10 µM) on α1β2γ2 and α4β2δ GABA receptor current modulation were explored by two-electrode voltage clamping. Prophylactic tandospirone administration reduced respiratory depression caused by anesthetics in rats. Tandospirone (0.1–8 mg/kg) increased SaO2 in rats treated with fentanyl (80 µg/kg) or midazolam (80 mg/kg) (P < 0.05). The ability of tandospirone to prevent respiratory depression was inhibited by the 5-hydroxytryptamine (5-HT)1 A receptor antagonist WAY100635 (1 mg/kg) (P < 0.05). Co-administration of tandospirone with dexmedetomidine or fentanyl did not affect α2a/2c or µ receptors activation. Tandospirone (10 µM) did not affect α1β2γ2 and α4β2δ GABA receptor modulation (P < 0.05). Overall, tandospirone ameliorated respiratory depression caused by anesthetics in rats through 5-HT1A receptor activation.