<p>To optimize screen quality for a better and healthier visual experience, it is essential to understand how photometric parameters impact ocular physiological parameters. However, the relationship between these photometric and physiological parameters has still not been clearly defined. In this study, time series data of accommodative response and ocular imaging quality at various time points during screen viewing were analyzed, examining different screen photometric parameters. The concept of “tolerance duration” based on these time series curves was introduced. The findings indicate that accommodative response is sensitive to screen brightness, while ocular imaging quality is affected by spectral power distribution. The mathematic models of time-dependent dynamics for both accommodative response and ocular imaging quality were developed, consisting of positive and negative forces. The accommodative response displayed an exponential decay and linear increase pattern, whereas the ocular imaging quality corresponded more closely to sigmoid functions. This innovative model could broaden the understanding of ocular physiological changes during screen use. Additionally, it may offer useful insights for optimizing screen photometric parameters and assist in monitoring ocular responses in clinical research.</p>