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Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022

  • Maren Doenhardt,
  • Markus Hufnagel,
  • Natalie Diffloth,
  • Johannes Hübner,
  • René Mauer,
  • Dominik T. Schneider,
  • Arne Simon,
  • Tobias Tenenbaum,
  • Andreas Trotter,
  • Jakob Armann,
  • Reinhard Berner,
  • Aischa Abuleed,
  • Michal Achenbach,
  • Grazyna Adamiak-Brych,
  • Martina Aderhold,
  • Sandra Akanbi,
  • Madaa Akmeinasi,
  • Norbert Albers,
  • Louisa Ammann-Schnell,
  • Kristin Anders,
  • Theresa Andree,
  • Judith Anhalt,
  • Nils Apel,
  • Stefan Arens,
  • Christoph Aring,
  • Caroline Armbruster,
  • Inken Arnold,
  • Thomas Austgen,
  • Igor Bachmat,
  • Lena Balles,
  • Arne Baltaci,
  • Theresa Baranowski,
  • Sylvia Barth,
  • Stefan Barth,
  • María Paula Bateman Castrillón,
  • Susanne Baumann,
  • Lisa Baumbach,
  • Boris Becker,
  • Angelina Beer,
  • Gerald Beier,
  • Christiane Bell,
  • Antigoni Bellou,
  • Stephanie Bentz,
  • Josephine Berens,
  • Elisabeth Berger,
  • Simon Berzel,
  • Julia Bley,
  • Helga Blumberg,
  • Stefanie Blume,
  • Kai Böckenholt,
  • Andreas Böckmann,
  • Sebastian Bode,
  • Julie Boever,
  • Leonie Böhm,
  • Henning Böhme,
  • Carsten Bölke,
  • Monika-Maria Borchers,
  • Hans Martin Bosse,
  • Michael Böswald,
  • Katharina Botschen,
  • Franka Böttger,
  • Sandra Braun,
  • Britta Brenner,
  • Folke Brinkmann,
  • Beate Bruggmoser,
  • Jürgen Brunner,
  • Florian L. Bucher,
  • Laura Buchtala,
  • Jörg Budde,
  • Reinhard Bullmann,
  • Bernhard Bungert,
  • Dorothea Büsdorf,
  • Lisa Cardellini,
  • Chiara Cattaneo,
  • Cho-Ming Chao,
  • Laura Chaparro,
  • Claus Christians,
  • Kerstin Cremer,
  • Gordana Cvetanovic,
  • Alina Czwienzek,
  • Madura Daluwatta,
  • Gideon de Sousa,
  • Metin Degirmenci,
  • Fenja Dejas,
  • Janne Deutschmann,
  • Ute Deutz,
  • Iryna Dobrianska,
  • Katharina Döhring,
  • Helena Donath,
  • Arne Dresen,
  • Svenja Dreßen,
  • Melissa Drozdek,
  • Jens Dubenhorst,
  • Max Dunker,
  • Heinrich Eberhardt,
  • Franziska Ebert,
  • Hannah Echelmeyer,
  • Kerstin Ehrentraut,
  • Christoph Ehrsam,
  • Thea Angelika Eichelmann,
  • Hanna Ellmann,
  • Matthias Endmann,
  • Stefanie Endres,
  • Elisa Endres,
  • Matthias Engler,
  • Denise Engler,
  • David Eppler,
  • Oxana Erbe,
  • Michael Erdmann,
  • Annika Esser,
  • Stephan Ewest,
  • Philipp Falderbaum,
  • Lena Faßbender,
  • Simone Ferber,
  • Andreas Fiedler,
  • Magdalena Fischer,
  • Doris Fischer,
  • Elisabeth Fischer-Ging,
  • Isabel Fischer-Schmidt,
  • Ann-Sophie Fleischer,
  • Simon Flümann,
  • Denise Focke,
  • Svenja Foth,
  • Réka Fövényesi,
  • Svenja Frank,
  • Christian Fremerey,
  • Holger Frenzke,
  • Peter Freudenberg,
  • Mirjam Freudenhammer,
  • Christina Fritsch,
  • Stefanie Frohn,
  • Sylvia Fuhrmann,
  • Veronika Galajda Pavlíková,
  • Lukas Galow,
  • Monika Gappa,
  • Sabine Gärtner,
  • Hanga Gaspar,
  • Swen Geerken,
  • Julia Gehm,
  • Fabienne Gehrlein,
  • Norbert Geier,
  • Bernd Geißlreiter,
  • Martin Geltinger,
  • Marieke Gerlach,
  • Hubert Gerleve,
  • Carl Germann,
  • Verena Giesen,
  • Anna Girrbach,
  • Katharina Glas,
  • Lena Goetz,
  • Karoline Goj,
  • Christin Goldhardt,
  • Julia Gottschalk,
  • Jan-Felix Gottschlich,
  • Oliver Götz,
  • Katrin Gröger,
  • Sina Gronwald,
  • Anja Große Lordemann,
  • Anneke Grotheer,
  • Kathrin Gruber,
  • Judith Grüner,
  • Mike Grünwedel,
  • Lisa Gu,
  • Joya Gummersbach,
  • Stephan Haag,
  • Silke Haag,
  • Yasmin Hagel,
  • Swantje Hagemann,
  • Ina Hainmann,
  • Nikolaus Halwas,
  • Christof Hanke,
  • Jonas Härtner,
  • Caroline Haselier,
  • Anne Haupt,
  • Marie- Kristin Heffels,
  • Solvej Heidtmann,
  • Anna-Lena Heimer,
  • Christina Heinrich,
  • Annika Heinrich,
  • Lutz Hempel,
  • Christoph Hempel,
  • Silke Hennig,
  • Carolin Herbst,
  • Leonie Herholz,
  • Matthias Hermann,
  • Jan-Simon Hermens,
  • Marc Hertel,
  • Matthias Herzog,
  • Georg Heubner,
  • Julia Hildebrandt,
  • Kai-Alexandra Hilker,
  • Georg Hillebrand,
  • Matthias Himpel,
  • Claudia Hirschhausen,
  • Meike Höfer,
  • Liane Hoffmann,
  • Hans-Georg Hoffmann,
  • Mirjam Höfgen,
  • Nina Hofknecht,
  • Anja Hofmann,
  • Franziska Hofmann,
  • Katharina Holtkamp,
  • Mona Holzinger,
  • Anneke Homburg,
  • Thomas Hoppen,
  • Theresa Horst,
  • Andor Attila Horváth,
  • Markus Hummler,
  • Patrick Hundsdörfer,
  • Dieter Hüseman,
  • Conny Huster,
  • Nora Ido,
  • Phryne Ioannou,
  • Simone Jedwilayties,
  • Nils Jonas,
  • Cornelia Junge,
  • Linda Junghanns,
  • Attila Kádár,
  • Mohammad Kaddour,
  • Lea Kahlenberg,
  • Lukas Kaiser,
  • Petra Kaiser-Labusch,
  • Hermann Kalhoff,
  • Carola Kaltenhauser,
  • Elke Kaluza,
  • Wolfgang Kamin,
  • Cecil Varna Kanann,
  • Marcus Kania,
  • Cecil Varna Kannan,
  • Subha Kanneettukandathil,
  • Hendrik Karpinski,
  • Fabian Kassbeger,
  • Katja Kauertz,
  • Alexandra Kavvalou,
  • Svetlana Kelzon,
  • Immo Kern,
  • Elisabeth Kernen,
  • Mandy Kersten,
  • Marie-Sophie Keßner,
  • Daniel Kever,
  • Carolin Khakzar,
  • Johanna Kim,
  • Linda Kirner,
  • Martin Kirschstein,
  • Natalie Kiss,
  • Richard Kitz,
  • Christine Kleff,
  • Deborah Klein,
  • Leah Bernadette Klingel,
  • Christof Kluthe,
  • Jan Knechtel,
  • Marcel Kneißle,
  • Felix Knirsch,
  • Robin Kobbe,
  • Annemarie Köbsch,
  • Luisa Kohlen,
  • Christina Kohlhauser-Vollmuth,
  • Malte Kohns Vasconcelos,
  • Anne Königs,
  • Florian Konrad,
  • Sabrina Koop,
  • Julia Kopka,
  • Vanessa Kornherr,
  • Anna-Lena Kortenbusch,
  • Robert Kosteczka,
  • Holger Köster,
  • Sascha Kowski,
  • Hanna Kravets,
  • Ewa Krink,
  • Maren Krogh,
  • Rebecca Kuglin,
  • Reinhard Kühl,
  • Alena Kuhlmann,
  • Lea Maria Küpper-Tetzel,
  • Marion Kuska,
  • Sachiko Kwaschnowitz,
  • Martina Lange,
  • Franziska Lankes,
  • Julia Laubenbacher,
  • Gerrit Lautner,
  • Thanh Tung Le,
  • Verena Leykamm,
  • Hanna Libuschewski,
  • Lissy Lichtenstein,
  • Nadine Lienert,
  • Johannes Liese,
  • Ulla Lieser,
  • Ilona Lindl,
  • Torben Lindner,
  • Grischa Lischetzki,
  • Matthias Lohr,
  • Norbert Lorenz,
  • Niko Lorenzen,
  • Meike Löwe,
  • Daniela Lubitz,
  • Maria Lueg,
  • Lisa Luft,
  • Sa Luo,
  • Dominik Lwowsky,
  • Kathrin Machon,
  • Katharina Magin,
  • Thomas Maiberger,
  • Nadine Mand,
  • Andrea Markowsky,
  • Wiebke Maurer,
  • Maximilian Mauritz,
  • Theresa Meinhold,
  • Jochen Meister,
  • Melanie Menden,
  • Veronika Messer,
  • Jochen Meyburg,
  • Ulf Meyer,
  • Meike Meyer,
  • Jens Meyer,
  • Lars Meyer-Dobkowitz,
  • Peter Michel,
  • Marko Mohorovicic,
  • Laura Gabriela Moise,
  • Katharina Mönch,
  • Mathieu Monnheimer,
  • Yvonne Morawski,
  • Anja Morgenbrod,
  • Katrin Moritz,
  • David Muhmann,
  • Barbara Müksch,
  • Stefanie Müller,
  • Celina Müller,
  • Annemarie Müller,
  • Viola Müller,
  • Yvonne Müller,
  • Guido Müller,
  • Kathleen Müller-Franz,
  • Lutz Naehrlich,
  • Katharina Naghed,
  • Nicole Näther,
  • Tereza Nespor,
  • Tatjana Neuhierl,
  • Ann-Cathrine Neukamm,
  • Nam Nguyen,
  • Dirk Nielsen,
  • Klaus Niethammer,
  • Lydia Obernosterer,
  • Bernd Opgen-Rhein,
  • Iris Östreicher,
  • Esra Özdemir,
  • Nadejda Paduraru-Stoian,
  • Monique Palm,
  • Laura Parigger,
  • Nina Pellmann,
  • Theresa Pelster,
  • Ardina Pengu,
  • Falk Pentek,
  • Maurice Petrasch,
  • Antonia Maximina Pfennigs,
  • Aaron Pfisterer,
  • Anne Pfülb,
  • Lisa Piehler,
  • Ursula Pindur,
  • Markus Pingel,
  • Eva Pitsikoulis,
  • Jana Plutowski,
  • Wendy Poot,
  • Silvia Poralla,
  • Johanna Pottiez,
  • Simone Pötzsch,
  • Pablo Pretzel,
  • Clarissa Preuß,
  • Sven Propson,
  • Kateryna Puhachova,
  • Daniela Pütz,
  • Samina Quadri-Niazi,
  • Bernhard Queisser,
  • Jennifer Rambow,
  • Gunnar Rau,
  • Cornelius Rau,
  • Jacqueline Raum,
  • Heike Reck,
  • Victoria Rehmann,
  • Friedrich Reichert,
  • Thomas Reinhardt,
  • Carla Remy,
  • Hanna Renk,
  • Annika Richard,
  • Carolin Richter,
  • Nikolaus Rieber,
  • Sebastian Riedhammer,
  • Hannelore Ringe,
  • Bianca Rippberger,
  • Moritz Rohrbach,
  • Bettina Rokonal,
  • Caroline Rötger,
  • Anne Rothermel,
  • Ricarda Rox,
  • Alexander Rühlmann,
  • Marie-Cecile Ryckmanns,
  • Shahane Safarova,
  • Meila Salem,
  • Demet Sarial,
  • Helena Sartor,
  • Johanna Saxe,
  • Herbert Schade,
  • Miriam Schäfer,
  • Cecilia Scheffler,
  • Lena Brigitte Scheffler,
  • Marija Scheiermann,
  • Sandra Schiele,
  • Katja Schierloh,
  • Markus Schiller,
  • Benjamin Schiller,
  • Ruth Schilling,
  • Christof Schitke,
  • Christian Schlabach,
  • Theresa Schlichting,
  • Christian Schlick,
  • Christina Schlingschröder,
  • Florian Schmid,
  • Bastian Schmidt,
  • Josephine Schneider,
  • Dominik Schneider,
  • Hans-Christoph Schneider,
  • Alexander Schnelke,
  • Axel Schobeß,
  • Lothar Schrod,
  • Arne Schröder,
  • Sophia Schröder,
  • Theresia Schug,
  • Christopher Schulze,
  • Katharina Schuster,
  • Katharina Schütz,
  • Valeria Schwägerl,
  • Christoffer Seidel,
  • Christina Seidel,
  • Sabrina Seidel,
  • Josephin Seidel,
  • Katrin Seringhaus-Förster,
  • Armin Setzer,
  • Ralf Seul,
  • Wael Shabanah,
  • M. Ghiath Shamdeen,
  • Sebastian Sigl,
  • Isabel Simon,
  • Christina Solomou,
  • Ezgi Sönmez,
  • Lisa Spath,
  • Marco Spehl,
  • Thomas Stanjek,
  • Daniel Staude,
  • Janina Steenblock,
  • Sandro Stehle,
  • Michael Steidl,
  • Benedikt Steif,
  • Detlef Stein,
  • Franziska Stein,
  • Mathis Steindor,
  • Frank Stemberg,
  • Susanne Stephan,
  • Astrid Stienen,
  • Antje Stockmann,
  • Ursula Strier,
  • Heidi Ströle,
  • Roman Szudarek,
  • Van Hop Ta,
  • Kader Tan,
  • Rebecca Telaar,
  • Anna Telschow,
  • Lisa Teufel,
  • Stephanie Thein,
  • Lion Gabriel Thiel,
  • Lisa Thiesing,
  • Linda Thomas,
  • Julian Thomas,
  • Christian Timke,
  • Irmgard Toni,
  • Melcan Topuz,
  • Stefanie Trau,
  • Eva Tschiedel,
  • Sinty Tzimou,
  • Felix Uhlemann,
  • Torsten Uhlig,
  • Lieser Ulla,
  • Bartholomäus Urgatz,
  • Nicolaus v. Salis,
  • Sascha v. Soldenhoff,
  • Louisa van Bahlen,
  • Alijda Ingeborg van den Heuvel,
  • Kai Vehse,
  • Rebecca Veit,
  • Joshua Verleysdonk,
  • Andreas Viechtbauer,
  • Simon Vieth,
  • Markus Vogel,
  • Sophia von Blomberg,
  • Kira von der Decken,
  • Christian von Schnakenburg,
  • Julia Wagner,
  • Tatjana Wahjudi,
  • Karin Waldecker,
  • Ulrike Walden,
  • Ulrike Walther,
  • Mona Walther,
  • Christine Wegendt,
  • Götz Wehl,
  • Stefan Weichert,
  • Judith Anne Weiland,
  • Julia Weiß,
  • Laura Wendt,
  • Vera Wentzel,
  • Cornelia Wersal,
  • Ulrike Wetzel,
  • Barbara Wichmann,
  • Katharina Wickert,
  • Sandra Wieland,
  • Christiane Maria Wiethoff,
  • Hanna Wietz,
  • Florian Wild,
  • Rainer Willing,
  • Christian Windischmann,
  • Verena Winkeler,
  • Merle Winkelmann,
  • Sascha Winkler,
  • Laura Wißlicen,
  • Isabel Wormit-Frenzel,
  • Tobias Wowra,
  • Andreas Wroblewski,
  • Dominik Wulf,
  • Donald Wurm,
  • Malin Zaddach,
  • Julia Zahn,
  • Kai Zbieranek,
  • Lara-Sophie Zehnder,
  • Anne Zeller,
  • Martin Zellerhoff,
  • Katharina Zerlik,
  • Johanna Zimmermann,
  • Mária Zimolová,
  • Ulrich Zügge

摘要

By means of a nationwide, prospective, multicenter, observational cohort registry collecting data on 7375 patients with laboratory-confirmed SARS-CoV-2 admitted to children's hospitals in Germany, March 2020–November 2022, our study assessed the clinical features of children and adolescents hospitalized due to SARS-CoV-2, evaluated which of these patients might be at highest risk for severe COVID-19, and identified underlying risk factors. Outcomes tracked included: symptomatic infection, case fatality, sequelae at discharge and severe disease. Among reported cases, median age was one year, with 42% being infants. Half were admitted for reasons other than SARS-CoV-2. In 27%, preexisting comorbidities were present, most frequently obesity, neurological/neuromuscular disorders, premature birth, and respiratory, cardiovascular or gastrointestinal diseases. 3.0% of cases were admitted to ICU, but ICU admission rates varied as different SARS-CoV-2 variants gained prevalence. Main risk factors linked to ICU admission due to COVID-19 were: patient age (> 12 and 1–4 years old), obesity, neurological/neuromuscular diseases, Trisomy 21 or other genetic syndromes, and coinfections at time of hospitalization. With Omicron, the group at highest risk shifted to 1–4-year-olds. For both health care providers and the general public, understanding risk factors for severe disease is critical to informing decisions about risk-reduction measures, including vaccination and masking guidelines.