Epidemiology of 7375 children and adolescents hospitalized with COVID-19 in Germany, reported via a prospective, nationwide surveillance study in 2020–2022
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发表日期:
2024年1月2日
- Maren Doenhardt,
- Markus Hufnagel,
- Natalie Diffloth,
- Johannes Hübner,
- René Mauer,
- Dominik T. Schneider,
- Arne Simon,
- Tobias Tenenbaum,
- Andreas Trotter,
- Jakob Armann,
- Reinhard Berner,
- Aischa Abuleed,
- Michal Achenbach,
- Grazyna Adamiak-Brych,
- Martina Aderhold,
- Sandra Akanbi,
- Madaa Akmeinasi,
- Norbert Albers,
- Louisa Ammann-Schnell,
- Kristin Anders,
- Theresa Andree,
- Judith Anhalt,
- Nils Apel,
- Stefan Arens,
- Christoph Aring,
- Caroline Armbruster,
- Inken Arnold,
- Thomas Austgen,
- Igor Bachmat,
- Lena Balles,
- Arne Baltaci,
- Theresa Baranowski,
- Sylvia Barth,
- Stefan Barth,
- María Paula Bateman Castrillón,
- Susanne Baumann,
- Lisa Baumbach,
- Boris Becker,
- Angelina Beer,
- Gerald Beier,
- Christiane Bell,
- Antigoni Bellou,
- Stephanie Bentz,
- Josephine Berens,
- Elisabeth Berger,
- Simon Berzel,
- Julia Bley,
- Helga Blumberg,
- Stefanie Blume,
- Kai Böckenholt,
- Andreas Böckmann,
- Sebastian Bode,
- Julie Boever,
- Leonie Böhm,
- Henning Böhme,
- Carsten Bölke,
- Monika-Maria Borchers,
- Hans Martin Bosse,
- Michael Böswald,
- Katharina Botschen,
- Franka Böttger,
- Sandra Braun,
- Britta Brenner,
- Folke Brinkmann,
- Beate Bruggmoser,
- Jürgen Brunner,
- Florian L. Bucher,
- Laura Buchtala,
- Jörg Budde,
- Reinhard Bullmann,
- Bernhard Bungert,
- Dorothea Büsdorf,
- Lisa Cardellini,
- Chiara Cattaneo,
- Cho-Ming Chao,
- Laura Chaparro,
- Claus Christians,
- Kerstin Cremer,
- Gordana Cvetanovic,
- Alina Czwienzek,
- Madura Daluwatta,
- Gideon de Sousa,
- Metin Degirmenci,
- Fenja Dejas,
- Janne Deutschmann,
- Ute Deutz,
- Iryna Dobrianska,
- Katharina Döhring,
- Helena Donath,
- Arne Dresen,
- Svenja Dreßen,
- Melissa Drozdek,
- Jens Dubenhorst,
- Max Dunker,
- Heinrich Eberhardt,
- Franziska Ebert,
- Hannah Echelmeyer,
- Kerstin Ehrentraut,
- Christoph Ehrsam,
- Thea Angelika Eichelmann,
- Hanna Ellmann,
- Matthias Endmann,
- Stefanie Endres,
- Elisa Endres,
- Matthias Engler,
- Denise Engler,
- David Eppler,
- Oxana Erbe,
- Michael Erdmann,
- Annika Esser,
- Stephan Ewest,
- Philipp Falderbaum,
- Lena Faßbender,
- Simone Ferber,
- Andreas Fiedler,
- Magdalena Fischer,
- Doris Fischer,
- Elisabeth Fischer-Ging,
- Isabel Fischer-Schmidt,
- Ann-Sophie Fleischer,
- Simon Flümann,
- Denise Focke,
- Svenja Foth,
- Réka Fövényesi,
- Svenja Frank,
- Christian Fremerey,
- Holger Frenzke,
- Peter Freudenberg,
- Mirjam Freudenhammer,
- Christina Fritsch,
- Stefanie Frohn,
- Sylvia Fuhrmann,
- Veronika Galajda Pavlíková,
- Lukas Galow,
- Monika Gappa,
- Sabine Gärtner,
- Hanga Gaspar,
- Swen Geerken,
- Julia Gehm,
- Fabienne Gehrlein,
- Norbert Geier,
- Bernd Geißlreiter,
- Martin Geltinger,
- Marieke Gerlach,
- Hubert Gerleve,
- Carl Germann,
- Verena Giesen,
- Anna Girrbach,
- Katharina Glas,
- Lena Goetz,
- Karoline Goj,
- Christin Goldhardt,
- Julia Gottschalk,
- Jan-Felix Gottschlich,
- Oliver Götz,
- Katrin Gröger,
- Sina Gronwald,
- Anja Große Lordemann,
- Anneke Grotheer,
- Kathrin Gruber,
- Judith Grüner,
- Mike Grünwedel,
- Lisa Gu,
- Joya Gummersbach,
- Stephan Haag,
- Silke Haag,
- Yasmin Hagel,
- Swantje Hagemann,
- Ina Hainmann,
- Nikolaus Halwas,
- Christof Hanke,
- Jonas Härtner,
- Caroline Haselier,
- Anne Haupt,
- Marie- Kristin Heffels,
- Solvej Heidtmann,
- Anna-Lena Heimer,
- Christina Heinrich,
- Annika Heinrich,
- Lutz Hempel,
- Christoph Hempel,
- Silke Hennig,
- Carolin Herbst,
- Leonie Herholz,
- Matthias Hermann,
- Jan-Simon Hermens,
- Marc Hertel,
- Matthias Herzog,
- Georg Heubner,
- Julia Hildebrandt,
- Kai-Alexandra Hilker,
- Georg Hillebrand,
- Matthias Himpel,
- Claudia Hirschhausen,
- Meike Höfer,
- Liane Hoffmann,
- Hans-Georg Hoffmann,
- Mirjam Höfgen,
- Nina Hofknecht,
- Anja Hofmann,
- Franziska Hofmann,
- Katharina Holtkamp,
- Mona Holzinger,
- Anneke Homburg,
- Thomas Hoppen,
- Theresa Horst,
- Andor Attila Horváth,
- Markus Hummler,
- Patrick Hundsdörfer,
- Dieter Hüseman,
- Conny Huster,
- Nora Ido,
- Phryne Ioannou,
- Simone Jedwilayties,
- Nils Jonas,
- Cornelia Junge,
- Linda Junghanns,
- Attila Kádár,
- Mohammad Kaddour,
- Lea Kahlenberg,
- Lukas Kaiser,
- Petra Kaiser-Labusch,
- Hermann Kalhoff,
- Carola Kaltenhauser,
- Elke Kaluza,
- Wolfgang Kamin,
- Cecil Varna Kanann,
- Marcus Kania,
- Cecil Varna Kannan,
- Subha Kanneettukandathil,
- Hendrik Karpinski,
- Fabian Kassbeger,
- Katja Kauertz,
- Alexandra Kavvalou,
- Svetlana Kelzon,
- Immo Kern,
- Elisabeth Kernen,
- Mandy Kersten,
- Marie-Sophie Keßner,
- Daniel Kever,
- Carolin Khakzar,
- Johanna Kim,
- Linda Kirner,
- Martin Kirschstein,
- Natalie Kiss,
- Richard Kitz,
- Christine Kleff,
- Deborah Klein,
- Leah Bernadette Klingel,
- Christof Kluthe,
- Jan Knechtel,
- Marcel Kneißle,
- Felix Knirsch,
- Robin Kobbe,
- Annemarie Köbsch,
- Luisa Kohlen,
- Christina Kohlhauser-Vollmuth,
- Malte Kohns Vasconcelos,
- Anne Königs,
- Florian Konrad,
- Sabrina Koop,
- Julia Kopka,
- Vanessa Kornherr,
- Anna-Lena Kortenbusch,
- Robert Kosteczka,
- Holger Köster,
- Sascha Kowski,
- Hanna Kravets,
- Ewa Krink,
- Maren Krogh,
- Rebecca Kuglin,
- Reinhard Kühl,
- Alena Kuhlmann,
- Lea Maria Küpper-Tetzel,
- Marion Kuska,
- Sachiko Kwaschnowitz,
- Martina Lange,
- Franziska Lankes,
- Julia Laubenbacher,
- Gerrit Lautner,
- Thanh Tung Le,
- Verena Leykamm,
- Hanna Libuschewski,
- Lissy Lichtenstein,
- Nadine Lienert,
- Johannes Liese,
- Ulla Lieser,
- Ilona Lindl,
- Torben Lindner,
- Grischa Lischetzki,
- Matthias Lohr,
- Norbert Lorenz,
- Niko Lorenzen,
- Meike Löwe,
- Daniela Lubitz,
- Maria Lueg,
- Lisa Luft,
- Sa Luo,
- Dominik Lwowsky,
- Kathrin Machon,
- Katharina Magin,
- Thomas Maiberger,
- Nadine Mand,
- Andrea Markowsky,
- Wiebke Maurer,
- Maximilian Mauritz,
- Theresa Meinhold,
- Jochen Meister,
- Melanie Menden,
- Veronika Messer,
- Jochen Meyburg,
- Ulf Meyer,
- Meike Meyer,
- Jens Meyer,
- Lars Meyer-Dobkowitz,
- Peter Michel,
- Marko Mohorovicic,
- Laura Gabriela Moise,
- Katharina Mönch,
- Mathieu Monnheimer,
- Yvonne Morawski,
- Anja Morgenbrod,
- Katrin Moritz,
- David Muhmann,
- Barbara Müksch,
- Stefanie Müller,
- Celina Müller,
- Annemarie Müller,
- Viola Müller,
- Yvonne Müller,
- Guido Müller,
- Kathleen Müller-Franz,
- Lutz Naehrlich,
- Katharina Naghed,
- Nicole Näther,
- Tereza Nespor,
- Tatjana Neuhierl,
- Ann-Cathrine Neukamm,
- Nam Nguyen,
- Dirk Nielsen,
- Klaus Niethammer,
- Lydia Obernosterer,
- Bernd Opgen-Rhein,
- Iris Östreicher,
- Esra Özdemir,
- Nadejda Paduraru-Stoian,
- Monique Palm,
- Laura Parigger,
- Nina Pellmann,
- Theresa Pelster,
- Ardina Pengu,
- Falk Pentek,
- Maurice Petrasch,
- Antonia Maximina Pfennigs,
- Aaron Pfisterer,
- Anne Pfülb,
- Lisa Piehler,
- Ursula Pindur,
- Markus Pingel,
- Eva Pitsikoulis,
- Jana Plutowski,
- Wendy Poot,
- Silvia Poralla,
- Johanna Pottiez,
- Simone Pötzsch,
- Pablo Pretzel,
- Clarissa Preuß,
- Sven Propson,
- Kateryna Puhachova,
- Daniela Pütz,
- Samina Quadri-Niazi,
- Bernhard Queisser,
- Jennifer Rambow,
- Gunnar Rau,
- Cornelius Rau,
- Jacqueline Raum,
- Heike Reck,
- Victoria Rehmann,
- Friedrich Reichert,
- Thomas Reinhardt,
- Carla Remy,
- Hanna Renk,
- Annika Richard,
- Carolin Richter,
- Nikolaus Rieber,
- Sebastian Riedhammer,
- Hannelore Ringe,
- Bianca Rippberger,
- Moritz Rohrbach,
- Bettina Rokonal,
- Caroline Rötger,
- Anne Rothermel,
- Ricarda Rox,
- Alexander Rühlmann,
- Marie-Cecile Ryckmanns,
- Shahane Safarova,
- Meila Salem,
- Demet Sarial,
- Helena Sartor,
- Johanna Saxe,
- Herbert Schade,
- Miriam Schäfer,
- Cecilia Scheffler,
- Lena Brigitte Scheffler,
- Marija Scheiermann,
- Sandra Schiele,
- Katja Schierloh,
- Markus Schiller,
- Benjamin Schiller,
- Ruth Schilling,
- Christof Schitke,
- Christian Schlabach,
- Theresa Schlichting,
- Christian Schlick,
- Christina Schlingschröder,
- Florian Schmid,
- Bastian Schmidt,
- Josephine Schneider,
- Dominik Schneider,
- Hans-Christoph Schneider,
- Alexander Schnelke,
- Axel Schobeß,
- Lothar Schrod,
- Arne Schröder,
- Sophia Schröder,
- Theresia Schug,
- Christopher Schulze,
- Katharina Schuster,
- Katharina Schütz,
- Valeria Schwägerl,
- Christoffer Seidel,
- Christina Seidel,
- Sabrina Seidel,
- Josephin Seidel,
- Katrin Seringhaus-Förster,
- Armin Setzer,
- Ralf Seul,
- Wael Shabanah,
- M. Ghiath Shamdeen,
- Sebastian Sigl,
- Isabel Simon,
- Christina Solomou,
- Ezgi Sönmez,
- Lisa Spath,
- Marco Spehl,
- Thomas Stanjek,
- Daniel Staude,
- Janina Steenblock,
- Sandro Stehle,
- Michael Steidl,
- Benedikt Steif,
- Detlef Stein,
- Franziska Stein,
- Mathis Steindor,
- Frank Stemberg,
- Susanne Stephan,
- Astrid Stienen,
- Antje Stockmann,
- Ursula Strier,
- Heidi Ströle,
- Roman Szudarek,
- Van Hop Ta,
- Kader Tan,
- Rebecca Telaar,
- Anna Telschow,
- Lisa Teufel,
- Stephanie Thein,
- Lion Gabriel Thiel,
- Lisa Thiesing,
- Linda Thomas,
- Julian Thomas,
- Christian Timke,
- Irmgard Toni,
- Melcan Topuz,
- Stefanie Trau,
- Eva Tschiedel,
- Sinty Tzimou,
- Felix Uhlemann,
- Torsten Uhlig,
- Lieser Ulla,
- Bartholomäus Urgatz,
- Nicolaus v. Salis,
- Sascha v. Soldenhoff,
- Louisa van Bahlen,
- Alijda Ingeborg van den Heuvel,
- Kai Vehse,
- Rebecca Veit,
- Joshua Verleysdonk,
- Andreas Viechtbauer,
- Simon Vieth,
- Markus Vogel,
- Sophia von Blomberg,
- Kira von der Decken,
- Christian von Schnakenburg,
- Julia Wagner,
- Tatjana Wahjudi,
- Karin Waldecker,
- Ulrike Walden,
- Ulrike Walther,
- Mona Walther,
- Christine Wegendt,
- Götz Wehl,
- Stefan Weichert,
- Judith Anne Weiland,
- Julia Weiß,
- Laura Wendt,
- Vera Wentzel,
- Cornelia Wersal,
- Ulrike Wetzel,
- Barbara Wichmann,
- Katharina Wickert,
- Sandra Wieland,
- Christiane Maria Wiethoff,
- Hanna Wietz,
- Florian Wild,
- Rainer Willing,
- Christian Windischmann,
- Verena Winkeler,
- Merle Winkelmann,
- Sascha Winkler,
- Laura Wißlicen,
- Isabel Wormit-Frenzel,
- Tobias Wowra,
- Andreas Wroblewski,
- Dominik Wulf,
- Donald Wurm,
- Malin Zaddach,
- Julia Zahn,
- Kai Zbieranek,
- Lara-Sophie Zehnder,
- Anne Zeller,
- Martin Zellerhoff,
- Katharina Zerlik,
- Johanna Zimmermann,
- Mária Zimolová,
- Ulrich Zügge
摘要
By means of a nationwide, prospective, multicenter, observational cohort registry collecting data on 7375 patients with laboratory-confirmed SARS-CoV-2 admitted to children's hospitals in Germany, March 2020–November 2022, our study assessed the clinical features of children and adolescents hospitalized due to SARS-CoV-2, evaluated which of these patients might be at highest risk for severe COVID-19, and identified underlying risk factors. Outcomes tracked included: symptomatic infection, case fatality, sequelae at discharge and severe disease. Among reported cases, median age was one year, with 42% being infants. Half were admitted for reasons other than SARS-CoV-2. In 27%, preexisting comorbidities were present, most frequently obesity, neurological/neuromuscular disorders, premature birth, and respiratory, cardiovascular or gastrointestinal diseases. 3.0% of cases were admitted to ICU, but ICU admission rates varied as different SARS-CoV-2 variants gained prevalence. Main risk factors linked to ICU admission due to COVID-19 were: patient age (> 12 and 1–4 years old), obesity, neurological/neuromuscular diseases, Trisomy 21 or other genetic syndromes, and coinfections at time of hospitalization. With Omicron, the group at highest risk shifted to 1–4-year-olds. For both health care providers and the general public, understanding risk factors for severe disease is critical to informing decisions about risk-reduction measures, including vaccination and masking guidelines.