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<p>Foodborne listeriosis is one of the severe food-borne diseases affecting both animals and humans worldwide. No vaccine to control listeriosis in humans is available, while a relatively high level of hospitalization (up to 90%) and mortality (up to 20–30%). However, listeriosis is a vaccine-preventable veterinary disease in livestock, which serves as the main reservoirs and the principal source of this infection in humans. Here, we represent the high-quality draft genome of two variants of the second reference <i>Listeria monocytogenes</i> (Lm) strain, routinely attenuated from the ovine virulent Lm strain and used for decades as a live whole-cell veterinary vaccine ‘AUF’ (LWCV AUF). Overall, the genomes possessed 2,844/2,846 CDSs, a number of pseudogenes (92/88), 13 of 14 internalins, 6 LIPI-1 genes, 5 antibiotic resistance genes, 6 genes within ESAT-6 gene-cluster, associated with bacterial T7SS, a number of genes which provided Lm acid tolerance. Our work can be useful for the comparative analysis of factors involved in the protective activity and residual virulence of commercial and experimental vaccines against Lm-associated diseases.</p>

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High-quality draft genome of the Listeria monocytogenes, one more vaccine strain against livestock listeriosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月19日

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  • Valentina A. Feodorova,
  • Maxim S. Lavrukhin,
  • Sergey S. Zaitsev,
  • Alexey Zaberezhny,
  • Olga S. Larionova

摘要

Foodborne listeriosis is one of the severe food-borne diseases affecting both animals and humans worldwide. No vaccine to control listeriosis in humans is available, while a relatively high level of hospitalization (up to 90%) and mortality (up to 20–30%). However, listeriosis is a vaccine-preventable veterinary disease in livestock, which serves as the main reservoirs and the principal source of this infection in humans. Here, we represent the high-quality draft genome of two variants of the second reference Listeria monocytogenes (Lm) strain, routinely attenuated from the ovine virulent Lm strain and used for decades as a live whole-cell veterinary vaccine ‘AUF’ (LWCV AUF). Overall, the genomes possessed 2,844/2,846 CDSs, a number of pseudogenes (92/88), 13 of 14 internalins, 6 LIPI-1 genes, 5 antibiotic resistance genes, 6 genes within ESAT-6 gene-cluster, associated with bacterial T7SS, a number of genes which provided Lm acid tolerance. Our work can be useful for the comparative analysis of factors involved in the protective activity and residual virulence of commercial and experimental vaccines against Lm-associated diseases.