Scholarlink

<p>Painful diabetic neuropathy (PDN) is a debilitating complication of diabetes, yet its central nervous system pathogenesis remains poorly understood. We investigated transcriptomic alterations in the central amygdala (CeA) in a diabetic rat model exhibiting neuropathic pain behavior. Male Sprague-Dawley rats were intraperitoneally injected a single dose of streptozotocin to induce diabetes. Six weeks following administration, the development of neuropathic pain was confirmed by the von Frey filament test. Subsequently, RNA sequencing of the CeA tissues was performed. This dataset provides a transcriptomic resource of the CeA in a rat model of diabetes-associated neuropathic pain, which is publicly available to facilitate research into the central mechanisms of PDN.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Transcriptomic profiling of the central amygdala in a rat model of diabetes-associated neuropathic pain

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年4月20日

查看全文
  • Xiaomin Nie,
  • Jinling Yan,
  • Xiangjie Song,
  • Jiayin Yue,
  • Aijun Jiang,
  • Sijia Chu,
  • Wei Wang

摘要

Painful diabetic neuropathy (PDN) is a debilitating complication of diabetes, yet its central nervous system pathogenesis remains poorly understood. We investigated transcriptomic alterations in the central amygdala (CeA) in a diabetic rat model exhibiting neuropathic pain behavior. Male Sprague-Dawley rats were intraperitoneally injected a single dose of streptozotocin to induce diabetes. Six weeks following administration, the development of neuropathic pain was confirmed by the von Frey filament test. Subsequently, RNA sequencing of the CeA tissues was performed. This dataset provides a transcriptomic resource of the CeA in a rat model of diabetes-associated neuropathic pain, which is publicly available to facilitate research into the central mechanisms of PDN.