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<p>This dataset provides a longitudinal analysis of urinary metabolomic profiles from 198 children aged 1 month, 6 months, 1 year, 3 years, and 5 years. Demographic information, including birth history, feeding practices, parental atopic history, household income, and atopic disease status at different ages, was collected. Total and allergen-specific IgE levels (mite, egg, cow’s milk) were measured to evaluate allergic sensitization over time. Atopic disease status was also monitored at multiple time points to assess its development. The urinary metabolomic data, generated using advanced <sup>1</sup>H-nuclear magnetic resonance (NMR) spectroscopy, were processed and normalized to support robust metabolic modeling. This dataset aims to provide insights into the relationships among early growth, metabolomic changes, and the development of allergic sensitization and atopic diseases in early childhood.</p>

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A longitudinal 1H NMR-based urinary metabolomics dataset in a birth cohort for childhood atopic diseases

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月10日

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  • Yi-Hsin Kuo,
  • Chih-Yung Chiu,
  • Meng-Han Chiang,
  • Jing-Long Huang,
  • Kuan-Wen Su,
  • Ming-Han Tsai,
  • Man-Chin Hua,
  • Sui-Ling Liao,
  • Shen-Hao Lai,
  • Kuo-Wei Yeh

摘要

This dataset provides a longitudinal analysis of urinary metabolomic profiles from 198 children aged 1 month, 6 months, 1 year, 3 years, and 5 years. Demographic information, including birth history, feeding practices, parental atopic history, household income, and atopic disease status at different ages, was collected. Total and allergen-specific IgE levels (mite, egg, cow’s milk) were measured to evaluate allergic sensitization over time. Atopic disease status was also monitored at multiple time points to assess its development. The urinary metabolomic data, generated using advanced 1H-nuclear magnetic resonance (NMR) spectroscopy, were processed and normalized to support robust metabolic modeling. This dataset aims to provide insights into the relationships among early growth, metabolomic changes, and the development of allergic sensitization and atopic diseases in early childhood.