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<p>An adequate immune response is responsible for eradicating pathogens and reestablishing tissue homeostasis upon infection. However, in certain patients, immune processes become dysregulated, leading to sepsis which often results in life-threatening organ dysfunction, and the progression to septic shock is associated with mortality rates of up to 70–80%. The objective of the present data set is to facilitate the identification of transcriptomic signatures characteristic of septic shock and the stable, out of critical condition. A total of six patients were included in the study, with blood samples collected at two different stages – septic shock, at the time of discharge from the intensive care unit – of the disease. Following total RNA isolation, mRNA and microRNA levels were determined by NGS. The dataset’s significance is based on the fact that two samples of the same patient were analyzed, ensuring that any observed alteration in transcript levels is related to the change in medical condition, and the analysis included both mRNAs and microRNAs enabling a comprehensive gene expression and regulatory study.</p>

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A dataset of paired blood mRNA and microRNA sequencing across acute septic shock and recovery

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月14日

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  • Krisztina Molnár,
  • Katalin Maricza,
  • Zsuzsanna Elek,
  • Réka Kovács-Nagy,
  • Ábel Fóthi,
  • Zsófia Bánlaki,
  • Eszter Losoncz,
  • Bernadett Húri,
  • János Kádas,
  • Gergely Keszler,
  • Zsolt Rónai

摘要

An adequate immune response is responsible for eradicating pathogens and reestablishing tissue homeostasis upon infection. However, in certain patients, immune processes become dysregulated, leading to sepsis which often results in life-threatening organ dysfunction, and the progression to septic shock is associated with mortality rates of up to 70–80%. The objective of the present data set is to facilitate the identification of transcriptomic signatures characteristic of septic shock and the stable, out of critical condition. A total of six patients were included in the study, with blood samples collected at two different stages – septic shock, at the time of discharge from the intensive care unit – of the disease. Following total RNA isolation, mRNA and microRNA levels were determined by NGS. The dataset’s significance is based on the fact that two samples of the same patient were analyzed, ensuring that any observed alteration in transcript levels is related to the change in medical condition, and the analysis included both mRNAs and microRNAs enabling a comprehensive gene expression and regulatory study.